Uric acid levels, kidney function, and cardiovascular mortality in US adults: National Health and Nutrition Examination Survey (NHANES) 1988-1994 and 1999-2002.
Uric acid levels, kidney function, and cardiovascular mortality in US adults: National Health and Nutrition Examination Survey (NHANES) 1988-1994 and 1999-2002.
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DOI：
10.1053/j.ajkd.2014.04.024
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Peralta CA
中科院分区：
文献类型：
--
作者：
Odden MC;Amadu AR;Smit E;Lo L;Peralta CA
Chronic kidney disease (CKD) and hyperuricemia often coexist, and both conditions are increasing in prevalence in the United States. However, their shared role in cardiovascular risk remains highly debated. Cross-sectional and longitudinal. Participants in the National Health and Nutrition Examination Survey (NHANES) from 1988 to 2002 (n = 10,956); data were linked to mortality data from the National Death Index through December 31st, 2006. Serum uric acid concentration, categorized as the sex-specific lowest (<25th), middle (25th–<75th), and highest (≥75th) percentiles; and kidney function assessed by estimated glomerular filtration rate (eGFR) based on the CKD-EPI (CKD Epidemiology Collaboration) creatinine–cystatin C equation, and urinary albumin-creatinine ratio (ACR) Cardiovascular death and all-cause mortality. Uric acid levels were correlated with eGFRcr-cys (r = −0.29; p<0.001), and were only slightly correlated with ACR (r = 0.04; p<0.001). There were 2,203 deaths up until December 31st, 2006, of which 981 were due to cardiovascular causes. Overall, there was a U-shaped association between uric acid levels and cardiovascular mortality in both women and men, although the lowest risk of cardiovascular mortality occurred at a lower level of uric acid for women compared with men. There was an association between the highest quartile of uric acid and cardiovascular mortality even after adjustment for potential confounders (HR, 1.48; 95% CI, 1.13–1.96), although this association was attenuated after adjustment for ACR and eGFRcr-cys (HR, 1.25; 95% CI, 0.89–1.75). The pattern of association between uric acid levels and all-cause mortality was similar. GFR not measured; mediating events were not observed. High uric acid is associated with cardiovascular and all-cause mortality, although this relationship was no longer statistically significant after accounting for kidney function.
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影响因子：
3.3
作者：
Rho, Young Hee;Zhu, Yanyan;Choi, Hyon K.
通讯作者：
Choi, Hyon K.
DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
影响因子：
13.2
作者：
Iseki, K;Ikemiya, Y;Takishita, S
通讯作者：
Takishita, S
DOI：
10.2215/cjn.09420911
发表时间：
2012-04-01
影响因子：
9.8
作者：
Liu, Wan-Chun;Hung, Chi-Chih;Chen, Hung-Chun
通讯作者：
Chen, Hung-Chun
影响因子：
13.2
作者：
Chonchol, Michel;Shlipak, Michael G.;Fried, Linda F.
通讯作者：
Fried, Linda F.