Variant Ionotropic Receptors in the Malaria Vector Mosquito Anopheles gambiae Tuned to Amines and Carboxylic Acids.
Variant Ionotropic Receptors in the Malaria Vector Mosquito Anopheles gambiae Tuned to Amines and Carboxylic Acids.
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DOI：
10.1038/srep40297
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发表时间：
2017-01-09
影响因子：
4.6
通讯作者：
Zwiebel LJ
中科院分区：
文献类型：
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作者：
Pitts RJ;Derryberry SL;Zhang Z;Zwiebel LJ
The principal Afrotropical human malaria vector mosquito, Anopheles gambiae, remains a significant threat to global health. A critical component in the transmission of malaria is the ability of An. gambiae females to detect and respond to human-derived chemical kairomones in their search for blood meal hosts. The basis for host odor responses resides in olfactory receptor neurons (ORNs) that express chemoreceptors encoded by large gene families, including the odorant receptors (ORs) and the variant ionotropic receptors (IRs). While ORs have been the focus of extensive investigation, functional IR complexes and the chemical compounds that activate them have not been identified in An. gambiae. Here we report the transcriptional profiles and functional characterization of three An. gambiae IR (AgIr) complexes that specifically respond to amines or carboxylic acids - two classes of semiochemicals that have been implicated in mediating host-seeking by adult females but are not known to activate An. gambiae ORs (AgOrs). Our results suggest that AgIrs play critical roles in the detection and behavioral responses to important classes of host odors that are underrepresented in the AgOr chemical space.
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影响因子：
9.8
作者：
Benton, Richard;Sachse, Silke;Michnick, Stephen W;Vosshall, Leslie B
通讯作者：
Vosshall, Leslie B
DOI：
10.1073/pnas.0601107103
发表时间：
2006-09-05
影响因子：
11.1
作者：
Kwon, Hyung-Wook;Lu, Tan;Zwiebel, Laurence J.
通讯作者：
Zwiebel, Laurence J.
影响因子：
9.2
作者：
Lu, Tan;Qiu, Yu Tong;Zwiebell, Laurence J.
通讯作者：
Zwiebell, Laurence J.
DOI：
10.2987/8756-971x(2007)23
发表时间：
2007-01-01
影响因子：
1
作者：
Platzer, Edward G. -
通讯作者：
Platzer, Edward G. -
影响因子：
64.8
作者：
通讯作者：
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