MUTYH Gln324His gene polymorphism and genetic susceptibility for lung cancer in a Japanese population.
MUTYH Gln324His gene polymorphism and genetic susceptibility for lung cancer in a Japanese population.
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DOI：
10.1186/1756-9966-28-10
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发表时间：
2009-01-22
期刊：
影响因子：
--
通讯作者：
Takahashi J
中科院分区：
文献类型：
--
作者：
Miyaishi A;Osawa K;Osawa Y;Inoue N;Yoshida K;Kasahara M;Tsutou A;Tabuchi Y;Sakamoto K;Tsubota N;Takahashi J
碱基切除修复（BER）通路中DNA修复酶基因多态性可能导致遗传不稳定和肺癌的发生。我们研究了DNA修复基因多态性与肺癌之间的相互作用。我们使用PCR-RFLP分析了OGG 1 Ser 326 Cys和MUTYH Gln 324 His基因多态性与肺癌风险的关系。该研究涉及108名肺癌患者和121名非癌症对照，根据日本吸烟包年数分为非吸烟者、吸烟者。结果表明，MUTYH His/His基因型与Gln/Gln基因型相比，肺癌的危险性增加（校正比值比[OR] 3.03，置信区间[95%CI] 1.31-7.00，p = 0.010），而Gln/His基因型没有显著增加（调整OR 1.35，95%CI 0.70-2.61，p = 0.376）。MUTYH His/His基因型患腺癌和鳞状细胞癌的风险均处于临界增加水平（腺癌的调整OR 2.50，95%CI 0.95-6.62，p = 0.065;鳞状细胞癌的调整OR 3.20，95%CI 0.89-11.49，p = 0.075）。然而，OGG 1 Ser/Cys或Cys/Cys基因型与Ser/Ser基因型相比，患肺癌的风险并没有显著增加，包括腺癌或鳞癌。烟草暴露和MUTYH His/His基因型与Gln/Gln基因型相比的联合效应显示吸烟者肺癌风险显著相关，而非吸烟者肺癌风险没有显著增加（吸烟者校正OR 3.82，95%CI 1.22-12.00，p = 0.022;非吸烟者校正OR 2.60，95%CI 0.60-11.25，p = 0.200）。烟草暴露和OGG 1 Ser 326 Cys的影响也没有显示出肺癌的显著风险。我们的研究结果表明，MUTYH Gln 324 His多态性似乎在改变日本人群肺癌的风险中发挥重要作用。
Genetic polymorphisms of DNA repair enzymes in the base excision repair (BER) pathway, may lead to genetic instability and lung cancer carcinogenesis. We investigated the interactions among the gene polymorphisms in DNA repair genes and lung cancer. We analyzed associations among OGG1 Ser326Cys and MUTYH Gln324His gene polymorphisms in relation to lung cancer risk using PCR-RFLP. The study involved 108 lung cancer patients and 121 non-cancer controls divided into non-smokers, smokers according to pack-years smoked in Japanese. The results showed that the MUTYH His/His genotype compared with Gln/Gln genotype showed an increased risk for lung cancer (adjusted odds ratio [OR] 3.03, confidence interval [95%CI], 1.31–7.00, p = 0.010), whereas there was no significant increase for the Gln/His genotype (adjusted OR 1.35, 95%CI 0.70–2.61, p = 0.376). The MUTYH His/His genotype was at a borderline increased risk for both adenocarcinoma and squamous cell carcinoma (adjusted OR 2.50, 95%CI 0.95–6.62, p = 0.065 for adenocarcinoma; adjusted OR 3.20, 95%CI 0.89–11.49, p = 0.075 for squamous cell carcinoma, respectively). However, the OGG1 Ser/Cys or Cys/Cys genotypes compared with the Ser/Ser genotype did not have significantly increased risk for lung cancer, containing either adenocarcinoma or squamous cell carcinoma. The joint effect of tobacco exposure and the MUTYH His/His genotype compared with the Gln/Gln genotype showed a significant association with lung cancer risk in smokers, and there was not significantly increased in non-smokers (adjusted OR 3.82, 95%CI 1.22–12.00, p = 0.022 for smokers; adjusted OR 2.60, 95%CI 0.60–11.25, p = 0.200 for non-smokers, respectively). The effect of tobacco exposure and the OGG1 Ser326Cys showed also no significant risk for lung cancer. Our findings suggest that the MUTYH Gln324His polymorphism appear to play an important role in modifying the risk for lung cancer in the Japanese population.
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影响因子：
14.9
作者：
Ohtsubo, T;Nishioka, K;Nakabeppu, Y
通讯作者：
Nakabeppu, Y
影响因子：
56.9
作者：
Wood, RD;Mitchell, M;Lindahl, T
通讯作者：
Lindahl, T
影响因子：
3.8
作者：
Li, Haixin;Hao, Xishan;Chen, Kexin
通讯作者：
Chen, Kexin
DOI：
10.1186/1756-9966-27-49
发表时间：
2008-09-30
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Kasahara M;Osawa K;Yoshida K;Miyaishi A;Osawa Y;Inoue N;Tsutou A;Tabuchi Y;Tanaka K;Yamamoto M;Shimada E;Takahashi J
通讯作者：
Takahashi J
影响因子：
3.5
作者：
Yanaru-Fujisawa, R.;Matsumoto, T.;Iida, M.
通讯作者：
Iida, M.