Aspirin and risk for gastric cancer: a population-based case-control study in Sweden.
Aspirin and risk for gastric cancer: a population-based case-control study in Sweden.
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DOI：
10.1054/bjoc.2001.1702
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发表时间：
2001-04-06
影响因子：
8.8
通讯作者：
Nyrén O
中科院分区：
文献类型：
--
作者：
Akre K;Ekström AM;Signorello LB;Hansson LE;Nyrén O
虽然阿司匹林和其他非类固醇抗炎药(NSAIDs)与胃粘膜损伤有关，但它们可能会降低患胃癌的风险。在瑞典5个县的一项基于人群的病例对照研究中，我们采访了567例胃癌病例和1165名对照，了解他们使用止痛药的情况。这些病例被统一分类为亚型(贲门/非贲门)和组织学类型，并收集了有关其他已知胃癌危险因素的信息。对542人进行了幽门螺杆菌血清学检测。与从不服用阿司匹林的人相比，服用阿司匹林的人患胃癌的风险适度降低；经年龄、性别和社会经济地位调整后的优势比(OR)为0.7(95%CI=0.6-1.0)。胃癌风险随着阿司匹林使用频率的增加而降低(趋势P=0.02)。风险的降低对于贲门和非贲门肿瘤都是明显的，但对于弥漫性组织学类型尚不确定。没有观察到胃癌风险与非阿司匹林非类固醇抗炎药或其他研究的止痛药之间的明确联系。我们的发现支持了使用阿司匹林降低患胃癌风险的假设。©2001癌症研究活动http://www.bjcancer.com
While aspirin and other non-steroid anti-inflammatory drugs (NSAIDs) are associated with gastric mucosal damage, they might reduce the risk for gastric cancer. In a population-based case–control study in 5 Swedish counties, we interviewed 567 incident cases of gastric cancer and 1165 controls about their use of pain relievers. The cases were uniformly classified to subsite (cardia/non-cardia) and histological type and information collected on other known risk factors for gastric cancer. Helicobacter pylori serology was tested in a subset of 542 individuals. Users of aspirin had a moderately reduced risk of gastric cancer compared to never users; odds ratio (OR) adjusted for age, gender and socioeconomic status was 0.7 (95% CI = 0.6–1.0). Gastric cancer risk fell with increasing frequency of aspirin use (P for trend = 0.02). The risk reduction was apparent for both cardia and non-cardia tumours but was uncertain for the diffuse histologic type. No clear association was observed between gastric cancer risk and non-aspirin NSAIDs or other studied pain relievers. Our finding lends support to the hypothesis that use of aspirin reduces the risk for gastric cancer. © 2001 Cancer Research Campaign http://www.bjcancer.com
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影响因子：
2.9
作者：
Sawaoka, H;Kawano, S;Hori, M
通讯作者：
Hori, M
影响因子：
1.9
作者：
Hawkey, CJ
通讯作者：
Hawkey, CJ
DOI：
10.1016/s0952-3278(98)90079-5
发表时间：
1998-11-01
影响因子：
3
作者：
Sawaoka, H;Kawano, S;Hori, M
通讯作者：
Hori, M
DOI：
10.1111/apm.1965.64.1.31
发表时间：
1965-01-01
期刊：
ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA
影响因子：
--
作者：
LAUREN, P
通讯作者：
LAUREN, P
DOI：
10.1007/bf01359557
发表时间：
1989-01-01
期刊：
LANGENBECKS ARCHIV FUR CHIRURGIE
影响因子：
--
作者：
MISUMI, A;MURAKAMI, A;AKAGI, M
通讯作者：
AKAGI, M