Inflammatory markers and obstructive sleep apnea in obese children: the NANOS study.
Inflammatory markers and obstructive sleep apnea in obese children: the NANOS study.
复制标题
DOI：
10.1155/2014/605280
复制
发表时间：
2014
影响因子：
4.6
通讯作者：
Gozal D
中科院分区：
文献类型：
--
作者：
Gileles-Hillel A;Alonso-Álvarez ML;Kheirandish-Gozal L;Peris E;Cordero-Guevara JA;Terán-Santos J;Martinez MG;Jurado-Luque MJ;Corral-Peñafiel J;Duran-Cantolla J;Gozal D
介绍。肥胖和阻塞性睡眠呼吸暂停综合征 (OSA) 是常见的共存病症，与慢性低度炎症状态相关，而慢性低度炎症状态是某些认知、代谢和心血管疾病的基础。目的。旨在检查患有 OSA 的肥胖社区儿童与非 OSA 儿童相比的炎症标志物水平，及其与临床和多导睡眠图 (PSG) 变量的关联。方法。在这项横断面、前瞻性多中心研究中，随机选择健康肥胖的西班牙儿童（4-15 岁）并接受夜间 PSG，然后进行早晨空腹抽血。检测血浆样本中的多种炎症标志物。结果。 204 名儿童参与了这项研究； 75 人患有 OSA，其定义为阻塞性呼吸障碍指数 (RDI) 为 3 次/小时总睡眠时间 (TST)。 OSA 和非 OSA 儿童的体重指数、性别和年龄相似。单核细胞趋化蛋白-1 (MCP-1) 和纤溶酶原激活物抑制剂-1 (PAI-1) 水平在 OSA 儿童中显着较高，其中白细胞介素 6 浓度在中重度 OSA 中较高（即 AHI > 5/hrTST；P < 0.01），而 MCP-1 水平与更长时间的夜间高碳酸血症相关（P < 0.001）。结论。 IL-6、MCP-1 和 PAI-1 在社区肥胖儿童的 OSA 背景下发生改变，进一步强化了 OSA 等睡眠障碍的促炎作用。该试验已在 ClinicalTrials.gov NCT01322763 注册。
Introduction. Obesity and obstructive sleep apnea syndrome (OSA) are common coexisting conditions associated with a chronic low-grade inflammatory state underlying some of the cognitive, metabolic, and cardiovascular morbidities. Aim. To examine the levels of inflammatory markers in obese community-dwelling children with OSA, as compared to no-OSA, and their association with clinical and polysomnographic (PSG) variables. Methods. In this cross-sectional, prospective multicenter study, healthy obese Spanish children (ages 4–15 years) were randomly selected and underwent nocturnal PSG followed by a morning fasting blood draw. Plasma samples were assayed for multiple inflammatory markers. Results. 204 children were enrolled in the study; 75 had OSA, defined by an obstructive respiratory disturbance index (RDI) of 3 events/hour total sleep time (TST). BMI, gender, and age were similar in OSA and no-OSA children. Monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) levels were significantly higher in OSA children, with interleukin-6 concentrations being higher in moderate-severe OSA (i.e., AHI > 5/hrTST; P < 0.01), while MCP-1 levels were associated with more prolonged nocturnal hypercapnia (P < 0.001). Conclusion. IL-6, MCP-1, and PAI-1 are altered in the context of OSA among community-based obese children further reinforcing the proinflammatory effects of sleep disorders such as OSA. This trial is registered with ClinicalTrials.gov NCT01322763.
登录
查看更多内容
小儿阻塞性睡眠呼吸暂停中循环的adropin浓度：与内皮功能的潜在相关性。
DOI：
10.1016/j.jpeds.2013.05.040
发表时间：
2013-10
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Gozal D;Kheirandish-Gozal L;Bhattacharjee R;Molero-Ramirez H;Tan HL;Bandla HP
通讯作者：
Bandla HP
影响因子：
8
作者：
Hart, Chantelle N.;Carskadon, Mary A.;Wing, Rena
通讯作者：
Wing, Rena
影响因子：
5.6
作者：
Bagai, Kanika;Muldowney, James A. S., III;Malow, Beth A.
通讯作者：
Malow, Beth A.
影响因子：
5.8
作者：
Dahlman, I;Kaaman, M;Arner, P
通讯作者：
Arner, P
DOI：
10.1164/rccm.200711-1670oc
发表时间：
2008-05-15
影响因子：
24.7
作者：
Gozal, David;Capdevila, Oscar Sans;Kheirandish-Gozal, Leila
通讯作者：
Kheirandish-Gozal, Leila