Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders.
Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders.
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多酚和 Nrf2 信号通路在 LPS 妊娠障碍中的调节机制
DOI：
10.1155/2017/8254289
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发表时间：
2017
影响因子：
--
通讯作者：
Yin Y
中科院分区：
文献类型：
--
作者：
Hussain T;Tan B;Liu G;Murtaza G;Rahu N;Saleem M;Yin Y
早期胚胎丢失和不良生育结局是影响人类和动物的主要生殖障碍。内毒素通过与强大的细胞机制相互作用而诱导炎症，而细胞机制被认为是大量的生殖疾病，如胎儿吸收、早产、畸形、宫内生长受限、流产、神经管缺陷、胎儿死亡和骨骼发育迟缓。脂多糖引发的自由基过量产生导致氧化应激，氧化应激通过刺激核因子-κB和PPARγ转录因子而介导炎症。黄酮类化合物在自然界中大量存在，具有多种功能，孕期补充可激活Nrf2信号通路，从而引发妊娠障碍。进一步推测，在妊娠期间形成强抗氧化的子宫环境可以减轻出现在成人期的疾病。该综述的目的是集中于黄酮类化合物对氧化应激介导的妊娠损伤和异常结局的调节特性，以及Nrf2激活在妊娠障碍中的作用。这些发现将有助于为改善氧化应激诱导的妊娠障碍提供新的见解。
Early embryonic loss and adverse birth outcomes are the major reproductive disorders that affect both human and animals. The LPS induces inflammation by interacting with robust cellular mechanism which was considered as a plethora of numerous reproductive disorders such as fetal resorption, preterm birth, teratogenicity, intrauterine growth restriction, abortion, neural tube defects, fetal demise, and skeletal development retardation. LPS-triggered overproduction of free radicals leads to oxidative stress which mediates inflammation via stimulation of NF-κB and PPARγ transcription factors. Flavonoids, which exist in copious amounts in nature, possess a wide array of functions; their supplementation during pregnancy activates Nrf2 signaling pathway which encounters pregnancy disorders. It was further presumed that the development of strong antioxidant uterine environment during gestation can alleviate diseases which appear at adult stages. The purpose of this review is to focus on modulatory properties of flavonoids on oxidative stress-mediated pregnancy insult and abnormal outcomes and role of Nrf2 activation in pregnancy disorders. These findings would be helpful for providing new insights in ameliorating oxidative stress-induced pregnancy disorders.
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