c-fms expression is a molecular marker of human acute myeloid leukemias.
c-fms expression is a molecular marker of human acute myeloid leukemias.
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c-fms 表达是人类急性髓系白血病的分子标志物。
作者：
P. Dubreuil;H. Torres;M. Courcoul;F. Birg;P. Mannoni
The c-fms protooncogene product was identified as the CSF-1 or M-CSF receptor, a polypeptide growth factor that plays a major role in myelomonocytic differentiation. This led us to look for expression of c-fms in fresh acute myeloid leukemia (AML) cells, using Northern blot analysis. c-fms expression was found in the leukemic cells of 28 AML patients, regardless of their stage of differentiation, which was assessed in the French-American-British (FAB) classification. However, the level of c-fms expression was especially high in AML of the M5 stage. High levels of expression were not accompanied by either amplification or rearrangements of the c-fms gene in AML cell DNAs. In contrast, c-fms expression was not found in acute lymphoid leukemias, whether of T or B origin. Thus, c-fms expression appears as a specific molecular marker of leukemogenesis in the myeloid lineage.
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Interleukin 6 是人巨核细胞的体外分化因子。
影响因子：
5.4
作者：
Kimura,H;Ishibashi,T;Uchida,T;Maruyama,Y;Friese,P;Burstein,SA
通讯作者：
Burstein,SA
影响因子：
56.9
作者：
C. W. Rettenmier;J. H. Chen;M. Roussel;C. Sherr
通讯作者：
C. W. Rettenmier;J. H. Chen;M. Roussel;C. Sherr
CSF-1 与 5q33.1 的分配：调节造血作用的基因簇及其参与骨髓疾病中 5 号染色体长臂缺失的证据。
DOI：
10.1073/pnas.84.9.2970
发表时间：
1987
影响因子：
11.1
作者：
Pettenati,MJ;LeBeau,MM;Lemons,RS;Shima,EA;Kawasaki,ES;Larson,RA;Sherr,CJ;Diaz,MO;Rowley,JD
通讯作者：
Rowley,JD
GM-CSF 和 FMS 参与骨髓疾病缺失 (5q) 的证据。
DOI：
10.1126/science.3484837
发表时间：
1986
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
LeBeau,MM;Westbrook,CA;Diaz,MO;Larson,RA;Rowley,JD;Gasson,JC;Golde,DW;Sherr,CJ
通讯作者：
Sherr,CJ