Retinal tissue and microvasculature loss in COVID-19 infection.
Retinal tissue and microvasculature loss in COVID-19 infection.
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DOI：
10.1038/s41598-023-31835-x
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发表时间：
2023-03-29
影响因子：
4.6
通讯作者：
Freeman, William R.
中科院分区：
文献类型：
--
作者：
Kalaw, Fritz Gerald P.;Warter, Alexandra;Cavichini, Melina;Knight, Darren;Li, Alexandria;Deussen, Daniel;Galang, Carlo;Heinke, Anna;Mendoza, Veronica;Borooah, Shyamanga;Baxter, Sally L.;Bartsch, Dirk-Uwe;Cheng, Lingyun;Freeman, William R.
这项横断面研究旨在通过量化视网膜血管的完整性来调查永久性毛细血管损伤可能是长期新冠肺炎后遗症的基础的假说。参与者被分为三个亚组：未受新冠肺炎影响的正常对照组，接受门诊护理的轻度新冠肺炎病例，以及需要重症监护病房(ICU)和呼吸支持的重度新冠肺炎病例。排除了在被诊断为新冠肺炎感染之前有可能影响视网膜血管系统的全身疾病的患者。参与者接受了全面的眼科检查和由光谱域光学相干断层扫描(SD-OCT)获得的视网膜成像，以及使用OCT血管成像获得的血管密度。对31人的61只眼进行了研究。重度新冠肺炎组黄斑外侧3 mm处视网膜体积明显减小(p = 0.02)。重度新冠肺炎组视网膜总血管密度显著低于正常组和轻度新冠肺炎组(p = 分别为0.004和0.0057)。新冠肺炎重度组中、深层毛细血管丛明显低于其他组(p <； 0.05)。视网膜组织和微血管丢失可能是新冠肺炎严重程度的生物标志物。对新冠肺炎康复患者的视网膜进行进一步监测可能有助于进一步了解新冠肺炎的后遗症。
This cross-sectional study aimed to investigate the hypothesis that permanent capillary damage may underlie the long-term COVID-19 sequela by quantifying the retinal vessel integrity. Participants were divided into three subgroups; Normal controls who had not been affected by COVID-19, mild COVID-19 cases who received out-patient care, and severe COVID-19 cases requiring intensive care unit (ICU) admission and respiratory support. Patients with systemic conditions that may affect the retinal vasculature before the diagnosis of COVID-19 infection were excluded. Participants underwent comprehensive ophthalmologic examination and retinal imaging obtained from Spectral-Domain Optical Coherence Tomography (SD-OCT), and vessel density using OCT Angiography. Sixty-one eyes from 31 individuals were studied. Retinal volume was significantly decreased in the outer 3 mm of the macula in the severe COVID-19 group (p = 0.02). Total retinal vessel density was significantly lower in the severe COVID-19 group compared to the normal and mild COVID-19 groups (p = 0.004 and 0.0057, respectively). The intermediate and deep capillary plexuses in the severe COVID-19 group were significantly lower compared to other groups (p < 0.05). Retinal tissue and microvascular loss may be a biomarker of COVID-19 severity. Further monitoring of the retina in COVID-19-recovered patients may help further understand the COVID-19 sequela.
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影响因子：
0.9
作者：
Padhy SK;Dcruz RP;Kelgaonkar A
通讯作者：
Kelgaonkar A
DOI：
10.2147/opth.s309346
发表时间：
2021
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
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通讯作者：
Miller JB
影响因子：
3.9
作者：
Park, Seung Hun;Cho, Heeyoon;Shin, Yong Un
通讯作者：
Shin, Yong Un
影响因子：
--
作者：
Liu, Meng-Yuan;Zheng, Bo;Li, Jian-Ping
通讯作者：
Li, Jian-Ping
DOI：
10.1007/s00417-015-3143-7
发表时间：
2016-05-01
影响因子：
2.7
作者：
Di, Gong;Yu Weihong;Dong Fangtian
通讯作者：
Dong Fangtian