Graft thickness, graft folds, and aberrations after descemet stripping endothelial keratoplasty for fuchs dystrophy.
Graft thickness, graft folds, and aberrations after descemet stripping endothelial keratoplasty for fuchs dystrophy.
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DOI：
10.1016/j.ajo.2011.05.003
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发表时间：
2011-12
影响因子：
4.2
通讯作者：
Patel, Sanjay V.
中科院分区：
文献类型：
--
作者：
Seery, Loren S.;Nau, Cherie B.;McLaren, Jay W.;Baratz, Keith H.;Patel, Sanjay V.
确定Fuchs营养不良后弹力层剥脱内皮角膜移植术（DSEK）后人工晶状体眼的全眼高阶像差（HOA），并建立移植物厚度、HOA和视力之间的关系。横断面研究。在DSEK后24个月内，每隔一段时间测量人工晶状体眼的全眼HOA，并在植入相同类型球形人工透镜的其他健康人工晶状体对照眼中测量。波前误差由Hartmann-Shack像差仪在4 mm直径的光学区上评估。在DSEK眼中，通过使用体内共聚焦显微镜测量中央移植物厚度和基质移植物褶皱，并通过糖尿病视网膜病变的电子早期治疗研究方法确定最佳矫正视力（BCVA）。DSEK后24个月的总HOA（0.28 ± 0.11 μm，平均值± SD，n=17）高于人工晶状体对照组（0.16 ± 0.07 μm，n=25，p<0.001）;具体而言，DSEK后三叶形和四叶形更高。在24个月时，总HOA（r= 0.69，p<0.001）和移植物褶皱（r= 0.41，p= 0.02）与中央移植物厚度相关，BCVA与总HOA（r= 0.39，p=0.01）相关，但与移植物厚度无关（r=-0.24，p= 0.20，n=27）。与未治疗的角膜相比，DSEK后的全眼HOA更高。较厚的移植物与增加的HOA和更多的移植物褶皱相关，这表明供体微囊部分地促成了波前误差。虽然BCVA与DSEK后的总HOA弱相关，但与移植物厚度无关。
To determine whole eye high-order aberrations (HOAs) in pseudophakic eyes after Descemet stripping endothelial keratoplasty (DSEK) for Fuchs dystrophy, and to establish relationships between graft thickness, HOAs, and visual acuity. Cross-sectional study. Whole eye HOAs were measured in pseudophakic eyes at intervals through 24 months after DSEK, and in otherwise healthy pseudophakic control eyes implanted with the same type of spherical intraocular lens. Wavefront errors were assessed by a Hartmann-Shack aberrometer over a 4 mm-diameter optical zone. In DSEK eyes, central graft thickness and stromal graft folds were measured by using confocal microscopy in vivo, and best-corrected visual acuity (BCVA) was determined by the electronic Early Treatment of Diabetic Retinopathy Study method. Total HOAs at 24 months after DSEK (0.28 ± 0.11 μm, mean ± SD, n=17) were higher than those in pseudophakic controls (0.16 ± 0.07 μm, n=25, p<0.001); specifically, trefoil and quadrafoil were higher after DSEK. At 24 months, total HOAs (r= 0.69, p<0.001) and graft folds (r= 0.41, p= 0.02) were correlated with central graft thickness, and BCVA was correlated with total HOAs (r= 0.39, p=0.01) but not with graft thickness (r= −0.24, p= 0.20, n=27). Whole eye HOAs are higher after DSEK compared to untreated corneas. Thicker grafts are associated with increased HOAs and more graft folds, suggesting that the donor lenticule contributes, in part, to the wavefront errors. Although BCVA is weakly related to total HOAs after DSEK, it is not related to graft thickness.
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影响因子：
4.2
作者：
Patel, Sanjay V.;Mclaren, Jay W.;Baratz, Keith H.
通讯作者：
Baratz, Keith H.
影响因子：
--
作者：
Faia, LJ;Baratz, KH;Bourne, WM
通讯作者：
Bourne, WM
影响因子：
4.4
作者：
Seery, Loren S.;McLaren, Jay W.;Patel, Sanjay V.
通讯作者：
Patel, Sanjay V.
影响因子：
4.4
作者：
Guirao, A;Tejedor, J;Artal, P
通讯作者：
Artal, P
影响因子：
13.7
作者：
Terry, MA;Ousley, PJ
通讯作者：
Ousley, PJ