Wired for insight-recent advances in Caenorhabditis elegans neural circuits.

Wired for insight-recent advances in Caenorhabditis elegans neural circuits.
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DOI:
10.1016/j.conb.2021.02.009
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发表时间:
2021-08
影响因子:
5.7
通讯作者:
Jin Y
Jin Y
中科院分区:
医学2区
文献类型:
--
作者:
Byrd DT;Jin Y

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C. 40年前的elegans连接组学长期以来一直指导着神经元回路的机械研究。显微镜和计算程序的最新技术进步有助于重新审视这种连接组学,通过发现以前未报道的突触连接和生成神经网络底层行为的模型来扩展我们的知识。将来自单细胞转录组的信息与用于细胞特异性操作的优雅工具相结合,极大地增强了精确研究行为动物中单个神经元的能力。这篇简短的综述旨在提供一个关于连接组学的新信息和C. elegans神经系统,并讨论神经元回路的新发现。
The completion of C. elegans connectomics four decades ago has long guided mechanistic investigation of neuronal circuits. Recent technological advance in microscopy and computation programs have aided re-examination of this connectomics, expanding our knowledge by both uncovering previously unreported synaptic connections and also generating models for neural network underlying behaviors. Combining information from single cell transcriptome with elegant tools for cell-specific manipulation has greatly enhanced the ability to precisely investigate individual neurons in behaving animals. This mini-review aims to provide an overview of new information on connectomics and progress towards a molecular atlas of C. elegans nervous system, and discuss emerging findings on neuronal circuits.
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