Wired for insight-recent advances in Caenorhabditis elegans neural circuits.
Wired for insight-recent advances in Caenorhabditis elegans neural circuits.
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DOI:
10.1016/j.conb.2021.02.009
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发表时间:
2021-08
影响因子:
5.7
通讯作者:
Jin Y
中科院分区:
文献类型:
--
作者:
Byrd DT;Jin Y
The completion of C. elegans connectomics four decades ago has long guided mechanistic investigation of neuronal circuits. Recent technological advance in microscopy and computation programs have aided re-examination of this connectomics, expanding our knowledge by both uncovering previously unreported synaptic connections and also generating models for neural network underlying behaviors. Combining information from single cell transcriptome with elegant tools for cell-specific manipulation has greatly enhanced the ability to precisely investigate individual neurons in behaving animals. This mini-review aims to provide an overview of new information on connectomics and progress towards a molecular atlas of C. elegans nervous system, and discuss emerging findings on neuronal circuits.
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DOI:
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