Hypertension-induced vascular remodeling contributes to reduced cerebral perfusion and the development of spontaneous stroke in aged SHRSP rats.
Hypertension-induced vascular remodeling contributes to reduced cerebral perfusion and the development of spontaneous stroke in aged SHRSP rats.
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DOI：
10.1038/jcbfm.2009.246
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发表时间：
2010-04
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影响因子：
--
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中科院分区：
文献类型：
--
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自发性高血压卒中易感大鼠（SHRSPs）的中风特别有趣，因为其发病机制被认为与临床环境相似。本研究采用多模态磁共振成像——asl、DWI、T2、GRE、T1（对比前后），探讨自发性脑梗死的自然历史及脑灌注在疾病发展中的具体作用。12只雌性SHRSP大鼠（年龄：~1岁）在症状出现后1-3天内进行影像学检查。缺血性病变分布为：视觉28.1%，纹状体21.9%，运动感觉18.8%；12.5%是丘脑区，12.5%是听觉区，3.1%是额叶/边缘前区，3.1%是多个区域。与健康组织相比，缺血性病变的血流量明显减少。缺血性病变的特征是血管增生、血栓形成和受压。这些结果表明，缺血性病变的发展与高血压引起的血管重构和持续的低灌注有关。该模型可用于研究慢性高血压与继发卒中之间的关系，无论是一级预防还是二级预防。
Stroke in spontaneously-hypertensive stroke-prone rats (SHRSPs) is of particular interest because the pathogenesis is believed to be similar to that in the clinical setting. In this study, we employed multi-modal magnetic resonance imaging—ASL, DWI, T2, GRE, T1 (pre/post contrast)—to investigate the natural history of spontaneous cerebral infarction and the specific role of cerebral perfusion in disease development. Twelve female SHRSP rats (age: ~1yr) were imaged within 1-3 days of symptom onset. The distribution of ischemic lesions was: 28.1% visual, 21.9% striatal, 18.8% motorsensory; 12.5% thalamic, 12.5% auditory, 3.1% frontal/prelimbic, and 3.1% multiple areas. Ischemic lesions had significantly reduced blood flow in comparison to healthy tissue. Ischemic lesions were characterized by hyperplastic, thrombosed, and compressed vessels. These findings suggest that ischemic lesion development is related to hypertension-induced vascular remodeling and persistent hypoperfusion. This model should be useful for studying the relationship between chronic hypertension and subsequent stroke, both in terms of primary and secondary prevention.
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影响因子：
5
作者：
Jesmin, Subrina;Maeda, Seiji;Kato, Norihiro
通讯作者：
Kato, Norihiro
影响因子：
3
作者：
LEGRAND, MCM;BENESSIANO, J;LEVY, BI
通讯作者：
LEVY, BI
DOI：
10.1097/00004647-199911000-00008
发表时间：
1999-11-01
影响因子：
6.3
作者：
Mies, G;Hermann, D;Hossmann, KA
通讯作者：
Hossmann, KA
影响因子：
2.1
作者：
Savage, P;Jeng, AY
通讯作者：
Jeng, AY
影响因子：
64.8
作者：
HILBERT, P;LINDPAINTNER, K;LATHROP, GM
通讯作者：
LATHROP, GM