NetLogo agent-based models as tools for understanding the self-organization of cell fate, morphogenesis and collective migration of the zebrafish posterior Lateral Line primordium.
NetLogo agent-based models as tools for understanding the self-organization of cell fate, morphogenesis and collective migration of the zebrafish posterior Lateral Line primordium.
复制标题
基于 NetLogo 代理的模型作为了解斑马鱼后侧线原基的细胞命运、形态发生和集体迁移的自组织的工具。
DOI：
10.1016/j.semcdb.2019.12.015
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发表时间：
2020
影响因子：
7.3
通讯作者：
Chitnis,AjayB
中科院分区：
文献类型：
--
作者：
DalleNogare,Damian;Chitnis,AjayB
Interactions between primordium cells and their environment determines the self-organization of the zebrafish posterior Lateral Line primordium as it migrates under the skin from the ear to the tip of the tail forming and depositing neuromasts to spearhead formation of the posterior Lateral Line sensory system. In this review we describe how the NetLogo agent-based programming environment has been used in our lab to visualize and explore how self-generated chemokine gradients determine collective migration, how the dynamics of Wnt signaling can be used to predict patterns of neuromast deposition, and how previously defined interactions between Wnt and Fgf signaling systems have the potential to determine the periodic formation of center-biased Fgf signaling centers in the wake of a shrinking Wnt system. We also describe how NetLogo was used as a database for storing and visualizing the results ofin totolineage analysis of all cells in the migrating primordium. Together, the models illustrate how this programming environment can be used in diverse ways to integrate what has been learnt from biological experiments about the nature of interactions between cells and their environment, and explore how these interactions could potentially determine emergent patterns of cell fate specification, morphogenesis and collective migration of the zebrafish posterior Lateral Line primordium.
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DOI：
10.1093/bioinformatics/btt772
发表时间：
2014-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Starruß J;de Back W;Brusch L;Deutsch A
通讯作者：
Deutsch A
影响因子：
2.7
作者：
Li, Q;Shirabe, K;Kuwada, JY
通讯作者：
Kuwada, JY
影响因子：
2.1
作者：
Thorne, Bryan C.;Bailey, Alexander M.;Peirce, Shayn M.
通讯作者：
Peirce, Shayn M.
影响因子：
2.3
作者：
Moraru II;Schaff JC;Slepchenko BM;Blinov ML;Morgan F;Lakshminarayana A;Gao F;Li Y;Loew LM
通讯作者：
Loew LM
单细胞分辨率下迁移斑马鱼侧线原基的整体成像。
影响因子：
2.7
作者：
Nogare,DamianDalle;Nikaido,Masataka;Somers,Katherine;Head,Jeffery;Piotrowski,Tatjana;Chitnis,AjayB
通讯作者：
Chitnis,AjayB