Gene mapping within the T/t complex of the mouse. IV: The inverted MHC is intermingled with several t-lethal genes

Gene mapping within the T/t complex of the mouse. IV: The inverted MHC is intermingled with several t-lethal genes
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小鼠 T/t 复合体内的基因定位。

DOI:
10.1016/0092-8674(84)90464-1
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发表时间:
1984
期刊:
影响因子:
64.5
通讯作者:
K. Artzt
K. Artzt
中科院分区:
生物学1区
文献类型:
--
作者:
H. Shin;D. Bennett;K. Artzt

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利用经典遗传学、血清学和分子遗传学的结合,我们已经定位了单倍型中尽可能多的MHC成分。结果表明,整个MHC基因被包含在一个简单的倒位中,其基因的相对位置是完整的。此外,一些t致死突变与MHC的成分非常接近或混合在一起。在着丝粒末端,t12致死基因在Qa区的Tl和H-2D之间映射,而在远端,r5致死基因与H-2K密不可分。
Using a combination of classical genetics, serology, and molecular genetics, we have mapped as many as possible of the MHC components in t haplotypes. Results indicate that the whole MHC is included in a simple inversion with the relative positions of its genes being intact. Furthermore, some of the t-lethal mutations map very near to, or are intermingled with, components of the MHC. At the centromeric end the t12lethal maps between TL and H-2D in the Qa region, and distally the r5lethal is inseparable from H-2K.
DOI: 10.1017/s0016672300018929
发表时间: 1982
期刊: Genetical research
影响因子: --
作者:
Sturm,S;Figueroa,F;Klein,J
通讯作者: Klein,J
T 细胞淋巴瘤阶段特异性转化基因 Tlym-I 的分离和表征。
DOI: 10.1073/pnas.81.7.2227
发表时间: 1984
影响因子: 11.1
作者:
Lane,MA;Sainten,A;Doherty,KM;Cooper,GM
通讯作者: Cooper,GM