Age and diffusion tensor anisotropy in adolescent and adult patients with schizophrenia.
Age and diffusion tensor anisotropy in adolescent and adult patients with schizophrenia.
复制标题
DOI：
10.1016/j.neuroimage.2008.12.057
复制
发表时间：
2009-04-15
期刊：
影响因子：
5.7
通讯作者：
Hof PR
中科院分区：
文献类型：
--
作者：
Schneiderman JS;Buchsbaum MS;Haznedar MM;Hazlett EA;Brickman AM;Shihabuddin L;Brand JG;Torosjan Y;Newmark RE;Canfield EL;Tang C;Aronowitz J;Paul-Odouard R;Hof PR
精神分裂症患者弥散张量各向异性值所示的脑白质病理改变是公认的，但这一指标在发病时和慢性状态之间的差异还不是很清楚。为了探讨这些状态在精神分裂症疾病进展中的差异，我们获得了35例成年精神分裂症和分裂情感障碍患者、23名首次精神分裂症发作的青少年和年龄和性别匹配的对照组(33名成年人和15名青少年)的1.5T扩散张量各向异性图像。使用Talairach和Tournoux地图集的立体定位坐标对被选为精神分裂症前额叶执行缺陷显著的主要皮质白质束感兴趣区域进行了评估。用多因素方差分析方法对双侧大脑半球前-后和/或下-上方向的各束区域进行评估。额叶和其他脑区之间的区域，而不是颞叶、枕叶和大脑半球间的区域，在正常人和患者中显示出不同的衰老模式，表明精神分裂症患者这些区域的白质病理在发病和慢性状态之间并不稳定。这表明，参与颞叶白质缺陷连接的区域在青少年患者中已经很好地存在，而额叶病理继续从青春期发展到成年。
Findings of white matter pathology as indicated by diffusion tensor anisotropy values in schizophrenia are well established, but the differences in this measure between the onset of the disease and the chronic state are not well known. To investigate the differences between these states in the progression of the disease of schizophrenia we acquired 1.5 T diffusion tensor anisotropy images on 35 adult patients with schizophrenia and schizoaffective disorder, 23 adolescents having their first psychotic episode, and age and sex matched controls (33 adults and 15 adolescents). Regions of interest in major cortical white matter tracts chosen as salient to the prefrontal executive deficit in schizophrenia were assessed using stereotaxic coordinates from the Talairach and Tournoux atlas. Regions of each tract along anterior-posterior and/or inferior-superior directions in both hemispheres were evaluated in multiway ANOVA. Tracts between the frontal lobe and other brain regions, but not temporal, occipital and interhemispheric tracts, showed a differential aging pattern in normals and patients indicating that the white matter pathology in these regions is not stable between the onset and the chronic state in schizophrenia. This suggests that tracts involved in the connectivity of the temporal lobe white matter deficits were already well in place in adolescent patients, while frontal lobe pathology continues to develop from adolescence to adulthood.
登录
查看更多内容
影响因子：
4.5
作者：
BUCHSBAUM, MS;MANSOUR, CS;RICE, DM
通讯作者：
RICE, DM
影响因子：
3.2
作者：
Schneiderman, Jason S.;Buchsbaum, Monte S.;Hof, Patrick R.
通讯作者：
Hof, Patrick R.
影响因子：
4.5
作者：
White, Tonya;Kendi, Ayse Tuba Karagulle;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.
影响因子：
6.6
作者：
BENES, FM
通讯作者：
BENES, FM
影响因子：
10.6
作者：
Konopaske, Glenn T.;Dorph-Petersen, Karl-Anton;Lewis, David A.
通讯作者：
Lewis, David A.