Chronic Liver Diseases and the Microbiome-Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease.

Chronic Liver Diseases and the Microbiome-Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease.
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DOI:
10.1053/j.gastro.2020.10.056
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发表时间:
2021-01
期刊:
影响因子:
29.4
通讯作者:
--
中科院分区:
医学1区
文献类型:
--
作者:

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随着肥胖、非酒精性肝病和过度饮酒在世界范围内的流行,慢性肝病正在达到流行的程度。大多数患者即使患有终末期肝病,也不适合进行肝移植。越来越多的证据表明肠道微生物是许多肝病的基础,因此,需要更好的基于肠道微生物区系知识的诊断、预后和治疗方法。我们回顾了需要回答的问题,以成功地将我们对肠道微生物组的知识以及与肝病相关的变化转化为实践。
Chronic liver disease is reaching epidemic proportions with the increasing prevalence of obesity, nonalcoholic liver disease, and alcohol overuse worldwide. Most patients are not candidates for liver transplantation even if they have end-stage liver disease. There is growing evidence of a gut microbial basis for many liver diseases, therefore, better diagnostic, prognostic, and therapeutic approaches based on knowledge of gut microbiota are needed. We review the questions that need to be answered to successfully translate our knowledge of the intestinal microbiome and the changes associated with liver disease into practice.
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