Context Processing and the Neurobiology of Post-Traumatic Stress Disorder.
Context Processing and the Neurobiology of Post-Traumatic Stress Disorder.
复制标题
DOI：
10.1016/j.neuron.2016.09.039
复制
发表时间：
2016-10-05
期刊：
影响因子：
16.2
通讯作者：
Abelson JL
中科院分区：
文献类型：
--
作者：
Liberzon I;Abelson JL
临床和情感神经科学的进展正在将精神疾病重新定义为特定脑回路中细胞/分子功能障碍的症状表现。创伤后应激障碍（PTSD）就是这一进展的一个典范，人们对神经生物学系统的理解不断加深，有助于恐惧学习、显着性检测和情绪调节，从而解释了其大部分现象学和神经生物学。然而，许多特征仍然无法解释，并且更全面地解释症状和核心神经生物学的简约模型仍然难以捉摸。情境处理是海马-前额叶-丘脑回路的关键调节功能，使生物体能够消除线索的歧义并从世界中获取特定情况的含义。我们认为，这种情境处理回路中的失调是 PTSD 病理生理学的核心，解释了其大部分现象学和大部分生物学发现。了解这样的核心机制及其潜在的神经回路，将提高诊断的准确性和对风险因素的理解，从而增强我们开发预防性和“个性化”干预措施的能力。
Progress in clinical and affective neuroscience is redefining psychiatric illness as symptomatic expression of cellular/molecular dysfunctions in specific brain circuits. Post-traumatic stress disorder (PTSD) has been an exemplar of this progress, with improved understanding of neurobiological systems subserving fear learning, salience detection, and emotion regulation explaining much of its phenomenology and neurobiology. However, many features remain unexplained and a parsimonious model that more fully accounts for symptoms and the core neurobiology remains elusive. Contextual processing is a key modulatory function of hippocampal-prefrontal-thalamic circuitry, allowing organisms to disambiguate cues and derive situation-specific meaning from the world. We propose that dysregulation within this context-processing circuit is at the core of PTSD pathophysiology, accounting for much of its phenomenology and most of its biological findings. Understanding core mechanisms like this, and their underlying neural circuits, will sharpen diagnostic precision and understanding of risk factors, enhancing our ability to develop preventive and “personalized” interventions.
登录
查看更多内容
影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
影响因子：
2
作者：
Bergado-Acosta, Jorge R.;Sangha, Susan;Stork, Oliver
通讯作者：
Stork, Oliver
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
7.2
作者：
BOUTON, ME
通讯作者：
BOUTON, ME
影响因子：
3.5
作者：
Booth, V;Poe, GR
通讯作者：
Poe, GR