Effect of Oxidative Stress on Diaphragm Dysfunction and Exercise Intervention in Chronic Obstructive Pulmonary Disease.
Effect of Oxidative Stress on Diaphragm Dysfunction and Exercise Intervention in Chronic Obstructive Pulmonary Disease.
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氧化应激对慢性阻塞性肺疾病膈肌功能障碍的影响及运动干预
DOI：
10.3389/fphys.2021.684453
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发表时间：
2021
影响因子：
4
通讯作者：
Wu W
中科院分区：
文献类型：
--
作者：
Zhang B;Li P;Li J;Liu X;Wu W
慢性阻塞性肺疾病（COPD）可引起肺外损伤，例如膈肌功能障碍。氧化应激是导致COPD膈肌功能障碍的主要因素之一。运动对COPD膈肌功能障碍的防治具有积极作用，运动引起的膈肌结构和功能的变化与氧化应激的调节密切相关。因此，本文在综述COPD氧化应激及膈肌结构和功能变化的基础上，分析运动对COPD氧化应激和膈肌功能障碍的影响，探讨运动改善氧化应激的可能机制。研究发现，慢性阻塞性肺病的膈肌功能障碍包括肌肉力量、耐力和活动能力的下降。氧化应激主要通过蛋白质氧化、蛋白酶激活和钙敏感性降低影响COPD膈肌的结构和功能。运动对氧化应激水平和膈肌功能障碍的影响可能因运动强度、持续时间和方式而异。运动对COPD膈肌氧化应激的作用机制可能包括提高抗氧化能力、降低氧化酶活性和改善线粒体功能。
Chronic obstructive pulmonary disease (COPD) can cause extrapulmonary injury such as diaphragm dysfunction. Oxidative stress is one of the main factors causing diaphragm dysfunction in COPD. Exercise plays a positive role in the prevention and treatment of diaphragm dysfunction in COPD, and the changes in diaphragm structure and function induced by exercise are closely related to the regulation of oxidative stress. Therefore, on the basis of the review of oxidative stress and the changes in diaphragm structure and function in COPD, this article analyzed the effects of exercise on oxidative stress and diaphragm dysfunction in COPD and explored the possible mechanism by which exercise improves oxidative stress. Studies have found that diaphragm dysfunction in COPD includes the decline of muscle strength, endurance, and activity. Oxidative stress mainly affects the structure and function of the diaphragm in COPD through protein oxidation, protease activation and calcium sensitivity reduction. The effects of exercise on oxidative stress level and diaphragm dysfunction may differ depending on the intensity, duration, and style of exercise. The mechanism of exercise on oxidative stress in the diaphragm of COPD may include improving antioxidant capacity, reducing oxidase activity and improving mitochondrial function.
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影响因子：
24.3
作者：
Doucet, M;Debigaré, R;Maltais, F
通讯作者：
Maltais, F
影响因子：
6.9
作者：
Dos Santos Yamaguti, Wellington Pereira;Paulin, Elaine;Fernandes Carvalho, Celso Ricardo
通讯作者：
Fernandes Carvalho, Celso Ricardo
DOI：
10.1249/mss.0000000000001195
发表时间：
2017-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Bowen, T. Scott;Aakeroy, Lars;Bronstad, Eivind
通讯作者：
Bronstad, Eivind
DOI：
10.1513/pats.200906-051js
发表时间：
2010-02-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Debigare, Richard;Cote, Claude H;Maltais, Francois
通讯作者：
Maltais, Francois
DOI：
10.2147/copd.s28247
发表时间：
2012
影响因子：
2.8
作者：
Donaldson AV;Maddocks M;Martolini D;Polkey MI;Man WD
通讯作者：
Man WD