Colorectal cancer: epigenetic alterations and their clinical implications.
Colorectal cancer: epigenetic alterations and their clinical implications.
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DOI：
10.1016/j.bbcan.2017.09.003
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Lenz HJ
中科院分区：
文献类型：
--
作者：
Puccini A;Berger MD;Naseem M;Tokunaga R;Battaglin F;Cao S;Hanna DL;McSkane M;Soni S;Zhang W;Lenz HJ
结直肠癌(CRC)是一种具有不同分子和临床特征的异质性疾病，反映了全世界结直肠癌患者的广泛预后和治疗反应。在过去的十年中，我们对CRC表观基因组的了解有了很大的发展，现在人们认为，在每个肿瘤中存在的数千种表观遗传学改变中，有一小部分可以被认为是CRC驱动事件。DNA甲基化在结直肠癌中得到了最广泛的研究，包括一组具有不同分子和临床特征的患者，现在被归类为CpG岛甲基化表型(CIMP)。我们在检测表观遗传学改变的能力方面取得了重大进展，为我们提供了新的潜在生物标志物，用于诊断、预后和治疗目的。这篇综述旨在总结我们目前对结直肠癌发生的表观遗传学改变的了解，潜在的潜在的未来临床意义在结直肠癌患者的诊断、预后和治疗策略方面。
Colorectal cancer (CRC) is a heterogeneous disease with distinct molecular and clinical features, which reflects the wide range of prognostic outcomes and treatment responses observed among CRC patients worldwide. Our understanding of the CRC epigenome has been largely developed over the last decade and it is now believed that among thousands of epigenetic alterations present in each tumor, a small subgroup of these may be considered as a CRC driver event. DNA methylation profiles have been the most widely studied in CRC, which includes a subset of patients with distinct molecular and clinical features now categorized as CpG island methylator phenotype (CIMP). Major advances have been made in our capacity to detect epigenetic alterations, providing us with new potential biomarkers for diagnostic, prognostic and therapeutic purposes. This review aims to summarize our current knowledge about epigenetic alterations occurring in CRC, underlying their potential future clinical implications in terms of diagnosis, prognosis and therapeutic strategies for CRC patients.
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DOI：
10.1038/nrm4043
发表时间：
2015-09
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
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通讯作者：
Patel DJ
影响因子：
2.4
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影响因子：
3.8
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Soong R
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3.1
作者：
Ding Jie;Zhang Zhongmin;Zeng Liang
通讯作者：
Zeng Liang
DNMT和HDAC抑制剂诱导长时间重复序列编码的隐秘转录起始位点。
影响因子：
30.8
作者：
Brocks D;Schmidt CR;Daskalakis M;Jang HS;Shah NM;Li D;Li J;Zhang B;Hou Y;Laudato S;Lipka DB;Schott J;Bierhoff H;Assenov Y;Helf M;Ressnerova A;Islam MS;Lindroth AM;Haas S;Essers M;Imbusch CD;Brors B;Oehme I;Witt O;Lübbert M;Mallm JP;Rippe K;Will R;Weichenhan D;Stoecklin G;Gerhäuser C;Oakes CC;Wang T;Plass C
通讯作者：
Plass C