Neural responses during social reflection in relatives of schizophrenia patients: relationship to subclinical delusions.
Neural responses during social reflection in relatives of schizophrenia patients: relationship to subclinical delusions.
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DOI：
10.1016/j.schres.2014.05.033
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发表时间：
2014-08
影响因子：
4.5
通讯作者：
Holt, Daphne J.
中科院分区：
文献类型：
--
作者：
Brent, Benjamin K.;Seidman, Larry J.;Coombs, Garth, III;Keshavan, Matcheri S.;Moran, Joseph M.;Holt, Daphne J.
在精神分裂症以及具有遗传或临床风险的人群中，已经发现了自我和他人反思能力（“社会反思”[SR]）的缺陷。然而，这些异常的神经基础还不完全清楚。已知参与自我和其他处理的大脑区域网络的反应（例如，对16名精神分裂症患者的一级非精神病性亲属（RELS）和16名健康对照者（CONS）在SR过程中的内侧前额叶皮层（MPFC）、后扣带回皮层（PCC）和上级颞回（STG）进行了测量。由于先前的证据将该网络中的功能障碍与妄想联系起来，因此还检查了该网络的SR相关反应与亚临床妄想（使用Peters等人的妄想量表测量）之间的关联。与CONS相比，RELS显示左右PCC和STG的SR相关活性显著降低。此外，两组的反应幅度与妄想思维水平呈负相关。这些发现表明，支持SR的神经回路的异常功能与精神分裂症的遗传易感性有关，并赋予妄想信念的脆弱性。
Deficits in the capacity to reflect about the self and others (“social reflection” [SR]) have been identified in schizophrenia, as well as in people with a genetic or clinical risk for the disorder. However, the neural underpinnings of these abnormalities are incompletely understood. Responses of a network of brain regions known to be involved in self and other processing (e.g., medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and superior temporal gyrus (STG)) were measured during SR in 16 first-degree, non-psychotic relatives (RELS) of schizophrenia patients and 16 healthy controls (CONS). Because of prior evidence linking dysfunction in this network and delusions, associations between SR-related responses of this network and subclinical delusions (measured using the Peters et al. Delusions Inventory) were also examined. Compared with CONS, RELS showed significantly less SR-related activity of the right and left PCC and STG. Moreover, response magnitudes were negatively correlated with levels of delusional thinking across both groups. These findings suggest that aberrant function of the neural circuitry underpinning SR is associated with the genetic liability to schizophrenia and confers vulnerability to delusional beliefs.
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影响因子：
4.2
作者：
Brent, Benjamin K.;Coombs, Garth;Holt, Daphne J.
通讯作者：
Holt, Daphne J.
影响因子：
4
作者：
Galbraith, Niall;Manktelow, Ken;Morris, Neil
通讯作者：
Morris, Neil
影响因子：
4.4
作者：
Bedford NJ;Surguladze S;Giampietro V;Brammer MJ;David AS
通讯作者：
David AS
影响因子：
2.6
作者：
Dickerson, Bradford C.;Sperling, Reisa A.
通讯作者：
Sperling, Reisa A.
影响因子：
3.9
作者：
HAPPE, FGE
通讯作者：
HAPPE, FGE