Short- and potential long-term adverse health outcomes of COVID-19: a rapid review.

Short- and potential long-term adverse health outcomes of COVID-19: a rapid review.
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DOI:
10.1080/22221751.2020.1825914
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发表时间:
2020-12
影响因子:
13.2
通讯作者:
Wong ICK
Wong ICK
中科院分区:
医学2区
文献类型:
--
作者:
Leung TYM;Chan AYL;Chan EW;Chan VKY;Chui CSL;Cowling BJ;Gao L;Ge MQ;Hung IFN;Ip MSM;Ip P;Lau KK;Lau CS;Lau LKW;Leung WK;Li X;Luo H;Man KKC;Ng VWS;Siu CW;Wan EYF;Wing YK;Wong CSM;Wong KHT;Wong ICK

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2019年冠状病毒病(COVID-19)大流行已导致全球数百万患者感染,并通过扰乱日常生活间接影响到更多人。据报道,其他冠状病毒引起的类似疾病,即中东呼吸综合征(MERS)和严重急性呼吸综合征(SARS),也有长期不良后果。新出现的证据表明,COVID-19会对人体的不同系统产生不利影响。本综述总结了目前关于COVID-19短期不良健康结局的证据,并评估了潜在的长期不良结局的风险。发现主要不良结局影响不同的身体系统:免疫系统(包括但不限于吉兰-巴罗综合征和儿科炎症多系统综合征)、呼吸系统(肺纤维化和肺血栓栓塞)、心血管系统(心肌病和凝血功能障碍)、神经系统(感觉功能障碍和中风),以及皮肤和胃肠道表现、肝肾功能受损。COVID-19患者的心理健康也受到不利影响。照顾COVID-19幸存者的负担可能是巨大的。因此,政策制定者制定全面的战略,为医疗保健系统提供资源和能力是很重要的。未来需要开展流行病学研究,以进一步调查对COVID-19幸存者的长期影响。
The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of patients infected worldwide and indirectly affecting even more individuals through disruption of daily living. Long-term adverse outcomes have been reported with similar diseases from other coronaviruses, namely Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). Emerging evidence suggests that COVID-19 adversely affects different systems in the human body. This review summarizes the current evidence on the short-term adverse health outcomes and assesses the risk of potential long-term adverse outcomes of COVID-19. Major adverse outcomes were found to affect different body systems: immune system (including but not limited to Guillain-Barré syndrome and paediatric inflammatory multisystem syndrome), respiratory system (lung fibrosis and pulmonary thromboembolism), cardiovascular system (cardiomyopathy and coagulopathy), neurological system (sensory dysfunction and stroke), as well as cutaneous and gastrointestinal manifestations, impaired hepatic and renal function. Mental health in patients with COVID-19 was also found to be adversely affected. The burden of caring for COVID-19 survivors is likely to be huge. Therefore, it is important for policy makers to develop comprehensive strategies in providing resources and capacity in the healthcare system. Future epidemiological studies are needed to further investigate the long-term impact on COVID-19 survivors.
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