Translational opportunities in the prenatal immune environment: Promises and limitations of the maternal immune activation model.
Translational opportunities in the prenatal immune environment: Promises and limitations of the maternal immune activation model.
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DOI：
10.1016/j.nbd.2020.104864
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发表时间：
2020-07
影响因子：
6.1
通讯作者：
Van de Water J
中科院分区：
文献类型：
--
作者：
Bauman MD;Van de Water J
产前环境，特别是母胎免疫环境，已成为神经发育起源的中枢神经系统（CNS）疾病研究的目标领域。来自临床和临床前研究的证据表明，母体妊娠免疫环境的变化可以改变胎儿大脑发育，并增加某些神经发育障碍的风险。在这里，我们专注于一个产前动物模型-母体免疫激活（MIA）模型的翻译潜力。这一模型源于这样一种观察，即在怀孕期间暴露于感染的一部分孕妇生下一个孩子的风险增加，这个孩子后来被诊断患有神经发育障碍，如自闭症谱系障碍（ASD）或精神分裂症（SZ）。临床前MIA模型提供了一个系统，在其中探索因果关系，识别潜在的神经生物学机制，并最终开发新的治疗干预和预防策略。在这篇综述中，我们将强调来自临床和临床前研究的证据，这些证据将母胎免疫环境的变化与后代大脑和行为发育的持久变化联系起来。然后，我们将探讨MIA模型作为开发新型治疗干预措施的转化工具的前景和局限性。由于MIA模型的转化潜力一直是几篇优秀综述文章的重点，在这里，我们将重点关注MIA模型研究中最不发达的领域-新的预防策略和治疗干预措施。
The prenatal environment, and in particular, the maternal-fetal immune environment, has emerged as a targeted area of research for central nervous system (CNS) diseases with neurodevelopmental origins. Converging evidence from both clinical and preclinical research indicates that changes in the maternal gestational immune environment can alter fetal brain development and increase the risk for certain neurodevelopmental disorders. Here we focus on the translational potential of one prenatal animal model –the maternal immune activation (MIA) model. This model stems from the observation that a subset of pregnant women who are exposed to infection during pregnancy have an increased risk of giving birth to a child who will later be diagnosed with a neurodevelopmental disorder, such as autism spectrum disorder (ASD) or schizophrenia (SZ). The preclinical MIA model provides a system in which to explore causal relationships, identify underlying neurobiological mechanisms, and, ultimately, develop novel therapeutic interventions and preventative strategies. In this review, we will highlight converging evidence from clinical and preclinical research that links changes in the maternal-fetal immune environment with lasting changes in offspring brain and behavioral development. We will then explore the promises and limitations of the MIA model as a translational tool to develop novel therapeutic interventions. As the translational potential of the MIA model has been the focus of several excellent review articles, here we will focus on what is perhaps the least well developed area of MIA model research –novel preventative strategies and therapeutic interventions.
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影响因子：
10.6
作者：
Bale, Tracy L.;Baram, Tallie Z.;Brown, Alan S.;Goldstein, Jill M.;Insel, Thomas R.;McCarthy, Margaret M.;Nemeroff, Charles B.;Reyes, Teresa M.;Simerly, Richard B.;Susser, Ezra S.;Nestler, Eric J.
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DOI：
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