Translational regulation in mycobacteria and its implications for pathogenicity.
Translational regulation in mycobacteria and its implications for pathogenicity.
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DOI：
10.1093/nar/gky574
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发表时间：
2018-08-21
影响因子：
14.9
通讯作者：
Cortes T
中科院分区：
文献类型：
--
作者：
Sawyer EB;Grabowska AD;Cortes T
蛋白质合成是所有细胞生存和复制的基本要求。迄今为止，已经进行了大量的遗传和生物化学研究，以解决大肠杆菌中的翻译及其调节机制，但只有有限数量的研究调查了其他细菌中的这些过程，特别是在缓慢生长的细菌中，如结核分枝杆菌，人类结核病的病原体。在这篇综述中，我们强调了M的翻译机制的重要差异。结核菌与E.大肠杆菌，特别是存在两个额外的蛋白质和亚基稳定元件，如B9桥。我们还考虑了无领导翻译在M.结核建立潜伏感染，并在实验证据，翻译调节机制的运作，在分枝杆菌在压力适应，特别是集中在毒素抗毒素系统之间的差异，E。大肠杆菌和M.结核病和可调翻译保真度在赋予表型抗生素抗性中的作用。最后，我们考虑了这些差异的生物适应的背景下，M。结核病和讨论如何这些调节机制可以帮助开发新的治疗结核病。
Protein synthesis is a fundamental requirement of all cells for survival and replication. To date, vast numbers of genetic and biochemical studies have been performed to address the mechanisms of translation and its regulation in Escherichia coli, but only a limited number of studies have investigated these processes in other bacteria, particularly in slow growing bacteria like Mycobacterium tuberculosis, the causative agent of human tuberculosis. In this Review, we highlight important differences in the translational machinery of M. tuberculosis compared with E. coli, specifically the presence of two additional proteins and subunit stabilizing elements such as the B9 bridge. We also consider the role of leaderless translation in the ability of M. tuberculosis to establish latent infection and look at the experimental evidence that translational regulatory mechanisms operate in mycobacteria during stress adaptation, particularly focussing on differences in toxin-antitoxin systems between E. coli and M. tuberculosis and on the role of tuneable translational fidelity in conferring phenotypic antibiotic resistance. Finally, we consider the implications of these differences in the context of the biological adaptation of M. tuberculosis and discuss how these regulatory mechanisms could aid in the development of novel therapeutics for tuberculosis.
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DOI：
10.1126/science.aaa1193
发表时间：
2015-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Amunts A;Brown A;Toots J;Scheres SHW;Ramakrishnan V
通讯作者：
Ramakrishnan V
影响因子：
4.1
作者：
Dedon, Peter C.;Begley, Thomas J.
通讯作者：
Begley, Thomas J.
DOI：
10.1099/00221287-142-4-915
发表时间：
1996-04-01
期刊：
MICROBIOLOGY-UK
影响因子：
--
作者：
Andersson, SGE;Sharp, PM
通讯作者：
Sharp, PM
DOI：
10.1074/mcp.m112.018846
发表时间：
2013-05
期刊：
Molecular & cellular proteomics : MCP
影响因子：
--
作者：
Albrethsen J;Agner J;Piersma SR;Højrup P;Pham TV;Weldingh K;Jimenez CR;Andersen P;Rosenkrands I
通讯作者：
Rosenkrands I
影响因子：
3.2
作者：
Gomez, JE;McKinney, JD
通讯作者：
McKinney, JD