Progressive replacement of embryo-derived cardiac macrophages with age.
Progressive replacement of embryo-derived cardiac macrophages with age.
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随着年龄的增长，逐步替代了胚胎来源的心脏巨噬细胞。
DOI：
10.1084/jem.20140639
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发表时间：
2014-10-20
期刊：
影响因子：
--
通讯作者：
Sieweke MH
中科院分区：
文献类型：
--
作者：
Molawi K;Wolf Y;Kandalla PK;Favret J;Hagemeyer N;Frenzel K;Pinto AR;Klapproth K;Henri S;Malissen B;Rodewald HR;Rosenthal NA;Bajenoff M;Prinz M;Jung S;Sieweke MH
Molawi等人研究了出生后发育期间心脏中巨噬细胞的起源和细胞动力学。来自CX3CR1+胚胎祖细胞的心脏巨噬细胞持续到成年期，但这些细胞对常驻巨噬细胞的贡献在出生后下降，随着小鼠年龄的增长，自我更新减少。随着时间的推移，即使在没有炎症的情况下，心脏也会逐渐用骨髓来源的巨噬细胞重建。心脏巨噬细胞（cMΦ）对出生后早期心脏再生和成年心脏纤维化修复至关重要，但其起源和出生后发育过程中的细胞动力学尚未得到很好的表征。组织巨噬细胞可以来源于胚胎祖细胞或炎症期间的单核细胞。我们报告说，在出生后的第一周内，胚胎来源的居民CX3CR1+ cMΦ的人口多样化成MHCII+和MHCII−细胞。遗传命运作图表明，来自CX3CR1+胚胎祖细胞的cMΦ持续到成年期，但出生后，最初对居民cMΦ的高贡献下降。与此相一致，居民cMΦ的早期显著增殖率随着年龄的增长而下降，分化成亚群。骨髓（BM）重建实验显示所有cMΦ群体的单核细胞依赖性定量置换。此外，联体小鼠和非辐射受体小鼠的BM嵌合体显示出对cMΦ的缓慢但显著的供体贡献。总之，我们的观察结果表明，在心脏中，胚胎来源的cMΦ显示出随着年龄的增长而下降的自我更新，并逐渐被单核细胞来源的巨噬细胞取代，即使在没有炎症的情况下。
Molawi et al. examine the origin and cellular dynamics of macrophages in the heart during postnatal development. Cardiac macrophages derived from CX3CR1+ embryonic progenitors persist into adulthood, but the contribution of these cells to resident macrophages declines after birth with diminished self-renewal as the mice age. Over time, the heart is progressively reconstituted with bone marrow–derived macrophages, even in the absence of inflammation. Cardiac macrophages (cMΦ) are critical for early postnatal heart regeneration and fibrotic repair in the adult heart, but their origins and cellular dynamics during postnatal development have not been well characterized. Tissue macrophages can be derived from embryonic progenitors or from monocytes during inflammation. We report that within the first weeks after birth, the embryo-derived population of resident CX3CR1+ cMΦ diversifies into MHCII+ and MHCII− cells. Genetic fate mapping demonstrated that cMΦ derived from CX3CR1+ embryonic progenitors persisted into adulthood but the initially high contribution to resident cMΦ declined after birth. Consistent with this, the early significant proliferation rate of resident cMΦ decreased with age upon diversification into subpopulations. Bone marrow (BM) reconstitution experiments showed monocyte-dependent quantitative replacement of all cMΦ populations. Furthermore, parabiotic mice and BM chimeras of nonirradiated recipient mice revealed a slow but significant donor contribution to cMΦ. Together, our observations indicate that in the heart, embryo-derived cMΦ show declining self-renewal with age and are progressively substituted by monocyte-derived macrophages, even in the absence of inflammation.
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影响因子：
3.7
作者：
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DOI：
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发表时间：
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期刊：
The Journal of experimental medicine
影响因子：
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作者：
Chorro L;Sarde A;Li M;Woollard KJ;Chambon P;Malissen B;Kissenpfennig A;Barbaroux JB;Groves R;Geissmann F
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DOI：
10.1084/jem.20120340
发表时间：
2012-06-04
期刊：
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影响因子：
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影响因子：
15.3
作者：
van Furth, R;Cohn, Z A
通讯作者：
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影响因子：
30.5
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