Salt Preform Texturing of Absorbable Zn Substrates for Bone-implant Applications.

Salt Preform Texturing of Absorbable Zn Substrates for Bone-implant Applications.
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DOI:
10.1007/s11837-019-03971-1
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发表时间:
2020-05
期刊:
JOM (Warrendale, Pa. : 1989)
影响因子:
--
通讯作者:
Young ML
Young ML
中科院分区:
其他
文献类型:
--
作者:
Cockerill I;Su Y;Bitten R;Cloarec B;Aouadi S;Zhu D;Young ML

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表面粗糙度是改善骨-种植体接触面积以促进骨再生的一个重要因素,但这一方面尚未应用于可吸收金属。采用盐预制法,用细粒和粗粒盐制作了具有不同表面粗糙度的织构锌表面,并与抛光的对照样品进行了比较。用扫描电子显微镜(SEM)、表面粗糙度、腐蚀速率和体外细胞毒性对所得表面进行了表征。得到的纹理表面显示出微米大小的空洞和与初始盐颗粒大小一致的增加的粗糙度。与抛光的对照样品相比,腐蚀速度显著加快,前成骨细胞在纹理上显示出健康的形态。结果证实,有纹理的锌表面支持电池粘连,并可用于控制腐蚀速度。这项研究代表了一个重要的中间步骤,可以应用于骨植入应用的多孔可吸收金属支架。
Surface roughness is an important factor in improving the bone-implant contact area to enhance bone regeneration, yet this aspect has not been applied to absorbable metals. Textured zinc surfaces with varying degrees of surface roughness were produced using a salt-preform method with fine- and coarse-grained salts and compared to a polished control sample. The resulting surfaces were characterized by scanning electron microscopy (SEM), surface roughness, corrosion rates, and in vitro cytotoxicity. The resulting textured surfaces exhibit micron-sized cavities and increased roughness consistent with the initial salt particle size. The corrosion rate was shown to accelerate significantly as compared to the polished control sample, and pre-osteoblasts displayed healthy morphologies on the textures. The results confirm textured zinc surfaces support cell adhesion and can be used to control the corrosion rate. This study represents an important intermediate step that can be applied to porous absorbable metal scaffolds for bone-implant applications.
用于生物医学应用的可吸收金属的研究和开发的最新动态。
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