Helminth lifespan interacts with non-compliance in reducing the effectiveness of anthelmintic treatment.
Helminth lifespan interacts with non-compliance in reducing the effectiveness of anthelmintic treatment.
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DOI：
10.1186/s13071-018-2670-6
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发表时间：
2018-01-31
影响因子：
3.2
通讯作者：
Anderson RM
中科院分区：
文献类型：
--
作者：
Farrell SH;Anderson RM
针对土源性蠕虫和血吸虫寄生虫的大规模药物管理计划的成功部分取决于连续几轮大规模药物管理（MDA）治疗的依从性。 MDA 的影响很容易受到系统性不依从的影响，系统性不依从的定义是合格人群中的一部分在连续的治疗轮次中仍未得到治疗。系统性不合规对蠕虫传播动态的影响，进而对中断传播所需的治疗轮次的影响，取决于 MDA 所针对的寄生蠕虫。在这里，我们使用蛔虫和曼氏血吸虫传播的数学模型并结合系统性不依从性，研究了人类宿主中成虫寄生虫寿命和决定基本繁殖数 R0 大小的其他因素对目标人群所需的额外治疗轮数的影响。我们的分析表明，蠕虫寿命与系统性违规对寄生虫消除的影响之间存在很强的相互作用，并在简化的模型结构中证实了蛔虫和血吸虫寄生虫之间的影响存在差异。我们的分析表明，降低系统性不合规水平可能对治疗寿命较长的蠕虫寄生虫的大规模药物管理计划特别有利，并强调需要改进数据收集以了解合规性的影响。
The success of mass drug administration programmes targeting the soil-transmitted helminths and schistosome parasites is in part dependent on compliance to treatment at sequential rounds of mass drug administration (MDA). The impact of MDA is vulnerable to systematic non-compliance, defined as a portion of the eligible population remaining untreated over successive treatment rounds. The impact of systematic non-compliance on helminth transmission dynamics - and thereby on the number of treatment rounds required to interrupt transmission - is dependent on the parasitic helminth being targeted by MDA. Here, we investigate the impact of adult parasite lifespan in the human host and other factors that determine the magnitude of the basic reproductive number R0, on the number of additional treatment rounds required in a target population, using mathematical models of Ascaris lumbricoides and Schistosoma mansoni transmission incorporating systematic non-compliance. Our analysis indicates a strong interaction between helminth lifespan and the impact of systematic non-compliance on parasite elimination, and confirms differences in its impact between Ascaris and the schistosome parasites in a streamlined model structure. Our analysis suggests that achieving reductions in the level of systematic non-compliance may be of particular benefit in mass drug administration programmes treating the longer-lived helminth parasites, and highlights the need for improved data collection in understanding the impact of compliance.
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影响因子：
3
作者：
Adhikari B;James N;Newby G;von Seidlein L;White NJ;Day NP;Dondorp AM;Pell C;Cheah PY
通讯作者：
Cheah PY
影响因子：
3.2
作者：
Shuford KV;Turner HC;Anderson RM
通讯作者：
Anderson RM
影响因子：
2.9
作者：
Brooker SJ;Mwandawiro CS;Halliday KE;Njenga SM;Mcharo C;Gichuki PM;Wasunna B;Kihara JH;Njomo D;Alusala D;Chiguzo A;Turner HC;Teti C;Gwayi-Chore C;Nikolay B;Truscott JE;Hollingsworth TD;Balabanova D;Griffiths UK;Freeman MC;Allen E;Pullan RL;Anderson RM
通讯作者：
Anderson RM
影响因子：
3.2
作者：
Farrell SH;Truscott JE;Anderson RM
通讯作者：
Anderson RM
影响因子：
--
作者：
Brooker, S;Bethony, J;Hotez, PJ
通讯作者：
Hotez, PJ