Early B cell factor: Regulator of B lineage specification and commitment.
Early B cell factor: Regulator of B lineage specification and commitment.
复制标题
DOI：
10.1016/j.smim.2008.07.004
复制
发表时间：
2008-08
影响因子：
7.8
通讯作者：
Hagman, James
中科院分区：
文献类型：
--
作者：
Lukin, Kara;Fields, Scott;Hartley, Jacqueline;Hagman, James
关键词：
B lymphocytes are generated from hematopoietic stem cells in a series of steps controlled by transcription factors. One of the most important regulators of this process is Early B cell Factor (EBF). Multiple lines of evidence indicate that expression of EBF is a principle determinant of the B cell fate. In the absence of EBF, progenitor cells fail to express classical markers of B cells, including immunoglobulins. EBF drives B cell differentiation by activating the Pax5 gene and other genes required for the pre-B and B cell receptors. New evidence suggests that expression of EBF in common lymphoid progenitors directs B cell fate decisions. Specification and commitment of cells to the B cell lineage are further established by Pax5, which increases expression of EBF. Recently, it was demonstrated that both EBF and Pax5 contribute to the commitment of cells to the B lineage. Together, these studies confirm that EBF is a keystone in a regulatory network that coordinates B cell lineage specification and commitment.
登录
查看更多内容
DOI：
10.1084/jem.20042393
发表时间：
2005-03-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dias S;Silva H Jr;Cumano A;Vieira P
通讯作者：
Vieira P
影响因子：
5.6
作者：
Aravind, L;Koonin, EV
通讯作者：
Koonin, EV
影响因子：
30.5
作者：
Hu, Hui;Wang, Bin;Rao, Anjana
通讯作者：
Rao, Anjana
影响因子：
16
作者：
Cirillo, LA;Zaret, KS
通讯作者：
Zaret, KS
影响因子：
10.5
作者：
CZERNY, T;SCHAFFNER, G;BUSSLINGER, M
通讯作者：
BUSSLINGER, M