Graphene Oxide/RhPTH(1-34)/Polylactide Composite Nanofibrous Scaffold for Bone Tissue Engineering.
Graphene Oxide/RhPTH(1-34)/Polylactide Composite Nanofibrous Scaffold for Bone Tissue Engineering.
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DOI：
10.3390/ijms24065799
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发表时间：
2023-03-18
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
聚丙交酯（PLA）是最有前途的聚合物之一，由于其生物相容性和生物可降解性而被广泛用于修复受损组织。具有机械性能和成骨作用等多种性能的PLA复合材料已被广泛研究。本文采用溶液静电纺丝法制备了PLA/氧化石墨烯（GO）/甲状旁腺激素（rhPTH（1-34））纳米纤维膜。 PLA/GO/rhPTH(1-34)膜的拉伸强度为2.64 MPa，比纯PLA样品(1.26 MPa)高近110%。生物相容性和成骨分化试验表明，GO的添加并没有明显影响PLA的生物相容性，PLA/GO/rhPTH(1-34)膜的碱性磷酸酶活性约为PLA的2.3倍。这些结果表明PLA/GO/rhPTH(1-34)复合膜可能是骨组织工程的候选材料。
Polylactide (PLA) is one of the most promising polymers that has been widely used for the repair of damaged tissues due to its biocompatibility and biodegradability. PLA composites with multiple properties, such as mechanical properties and osteogenesis, have been widely investigated. Herein, PLA/graphene oxide (GO)/parathyroid hormone (rhPTH(1-34)) nanofiber membranes were prepared using a solution electrospinning method. The tensile strength of the PLA/GO/rhPTH(1-34) membranes was 2.64 MPa, nearly 110% higher than that of a pure PLA sample (1.26 MPa). The biocompatibility and osteogenic differentiation test demonstrated that the addition of GO did not markedly affect the biocompatibility of PLA, and the alkaline phosphatase activity of PLA/GO/rhPTH(1-34) membranes was about 2.3-times that of PLA. These results imply that the PLA/GO/rhPTH(1-34) composite membrane may be a candidate material for bone tissue engineering.
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