Strategies for Bone Regeneration: From Graft to Tissue Engineering.

Strategies for Bone Regeneration: From Graft to Tissue Engineering.
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DOI:
10.3390/ijms22031128
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发表时间:
2021-01-23
影响因子:
5.6
通讯作者:
Del Fattore A
Del Fattore A
中科院分区:
生物学2区
文献类型:
--
作者:
Battafarano G;Rossi M;De Martino V;Marampon F;Borro L;Secinaro A;Del Fattore A

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骨骼是一种再生器官,具有自我更新能力。事实上,它是一个非常动态的组织,需要不断重塑以保持其结构和功能。然而,在临床实践中,可以在患者中观察到骨愈合受损,需要通过使用天然骨移植物或合成骨移植物进行医疗干预来再生组织。组织工程所需的主要元素包括细胞、生长因子和支撑它们的支架材料。三种不同的材料(金属、陶瓷和聚合物)可用于创建适合骨再生的支架。已经对几种细胞类型与生物材料相结合进行了研究。在这篇综述中,我们描述了骨再生的可用选项,重点关注基于使用不同生物材料与细胞和生长因子相结合的组织工程策略。
Bone is a regenerative organ characterized by self-renewal ability. Indeed, it is a very dynamic tissue subjected to continuous remodeling in order to preserve its structure and function. However, in clinical practice, impaired bone healing can be observed in patients and medical intervention is needed to regenerate the tissue via the use of natural bone grafts or synthetic bone grafts. The main elements required for tissue engineering include cells, growth factors and a scaffold material to support them. Three different materials (metals, ceramics, and polymers) can be used to create a scaffold suitable for bone regeneration. Several cell types have been investigated in combination with biomaterials. In this review, we describe the options available for bone regeneration, focusing on tissue engineering strategies based on the use of different biomaterials combined with cells and growth factors.
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