SARS-CoV-2 seroprevalence in healthcare workers at a frontline hospital in Tokyo.
SARS-CoV-2 seroprevalence in healthcare workers at a frontline hospital in Tokyo.
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DOI：
10.1038/s41598-021-87688-9
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发表时间：
2021-04-16
影响因子：
4.6
通讯作者：
Takahashi K
中科院分区：
文献类型：
--
作者：
Fukuda H;Seyama K;Ito K;Ai T;Nojiri S;Hori S;Wakita M;Saito K;Shida Y;Nagura R;Hasegawa M;Kanemoto C;Tokuhara M;Okajima K;Yoshikawa Y;Katsuta N;Yamamoto T;Idei M;Horiuchi Y;Yamatani K;Misawa S;Naito T;Miida T;Sato H;Hattori N;Tabe Y;Takahashi K
医护人员是严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）感染的高危人群。冠状病毒病（COVID-19）的实际情况，特别是受影响较小的地区，尚未确定。本研究旨在评估在日本东京一线医院工作的医务人员中SARS-CoV-2的血清阳性率。在这项横断面观察性研究中，对同意的HCW进行筛查，包括医疗，护理和其他工作人员，作为强制性健康检查的一部分。记录受试者的筛选试验结果和临床特征。2020年7月6日至8月21日筛查的4147名参与者中，抗体血清阳性率为0.34%（14/4147）。高暴露风险的前线医务工作者与低暴露风险的其他环境中工作的医务工作者之间的血清阳性率没有显着差异。在SARS-CoV-2血清反应阳性的患者中，64%（9/14）的人不知道任何症状，并且之前未被诊断患有COVID-19。总之，这项研究提供了对日本HCW感染程度和免疫状态的见解，日本的COVID-19患病率相对较低。我们的研究结果有助于制定公共卫生政策，以控制COVID-19低强度地区的病毒传播。
Healthcare workers (HCWs) are highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The actual coronavirus disease (COVID-19) situation, especially in regions that are less affected, has not yet been determined. This study aimed to assess the seroprevalence of SARS-CoV-2 in HCWs working in a frontline hospital in Tokyo, Japan. In this cross-sectional observational study, screening was performed on consented HCWs, including medical, nursing, and other workers, as part of a mandatory health checkup. The screening test results and clinical characteristics of the participants were recorded. The antibody seroprevalence rate among the 4147 participants screened between July 6 and August 21, 2020, was 0.34% (14/4147). There was no significant difference in the seroprevalence rate between frontline HCWs with a high exposure risk and HCWs working in other settings with a low exposure risk. Of those seropositive for SARS-CoV-2, 64% (9/14) were not aware of any symptoms and had not previously been diagnosed with COVID-19. In conclusion, this study provides insights into the extent of infection and immune status in HCWs in Japan, which has a relatively low prevalence of COVID-19. Our findings aid in formulating public health policies to control virus spread in regions with low-intensity COVID-19.
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影响因子：
6.9
作者：
Fusco, F. M.;Pisaturo, M.;Punzi, R.
通讯作者：
Punzi, R.
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3.7
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影响因子：
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作者：
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通讯作者：
Tipples G
影响因子：
168.9
作者：
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通讯作者：
Remuzzi, Giuseppe
影响因子：
3.7
作者：
Psichogiou M;Karabinis A;Pavlopoulou ID;Basoulis D;Petsios K;Roussos S;Pratikaki M;Jahaj E;Protopapas K;Leontis K;Rapti V;Kotanidou A;Antoniadou A;Poulakou G;Paraskevis D;Sypsa V;Hatzakis A
通讯作者：
Hatzakis A