Antibodies against SARS-CoV-2 among health care workers in a country with low burden of COVID-19.
Antibodies against SARS-CoV-2 among health care workers in a country with low burden of COVID-19.
复制标题
DOI：
10.1371/journal.pone.0243025
复制
发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Hatzakis A
中科院分区：
文献类型：
--
作者：
Psichogiou M;Karabinis A;Pavlopoulou ID;Basoulis D;Petsios K;Roussos S;Pratikaki M;Jahaj E;Protopapas K;Leontis K;Rapti V;Kotanidou A;Antoniadou A;Poulakou G;Paraskevis D;Sypsa V;Hatzakis A
希腊是SARS-CoV-2传播有限的国家，累计感染发病率为0.12% （95% CI 0.06-0.26）。卫生保健工作者是公认的COVID-19风险群体。该研究旨在评估医院环境中SARS-CoV-2抗体的血清阳性率，并评估潜在的危险因素。来自两家医院的医护人员参与了这项研究。医院1是三级大学附属中心，参与COVID-19患者的护理，而医院2是三级专科心脏外科中心，未参与这些患者的护理。使用经过验证的CE快速IgM/IgG抗体即时检测。评估了与全球可用的参考分析方法的比较性能。1495人同意参与（回复率77%）。总体抗sars - cov -2加权患病率为1.26% (95% CI 0.43, 3.26)，医院1和医院2的抗sars - cov -2加权患病率分别为0.53% （95% CI 0.06, 2.78）和2.70% (95% CI 0.57, 9.19)，尽管研究的能力不足，无法检测到统计学上的显著差异。总体、医院1和医院2的血清患病率分别比一般人群的估计感染发生率高10倍、4倍和22倍。两家医院都注意到个人防护装备的使用不理想。鉴于SARS-CoV-2感染率负担较低，这些数据与国家预测一致，对第二波COVID-19流行的准备工作具有重要意义。
Greece is a country with limited spread of SARS-CoV-2 and cumulative infection attack rate of 0.12% (95% CI 0.06–0.26). Health care workers (HCWs) are a well-recognized risk group for COVID-19. The study aimed to estimate the seroprevalence of antibodies to SARS-CoV-2 in a nosocomial setting and assess potential risk factors. HCWs from two hospitals participated in the study. Hospital-1 was a tertiary university affiliated center, involved in the care of COVID-19 patients while hospital-2 was a tertiary specialized cardiac surgery center not involved in the care of these patients. A validated, CE, rapid, IgM/IgG antibody point-of-care test was used. Comparative performance with a reference globally available assay was assessed. 1,495 individuals consented to participate (response rate 77%). The anti-SARS-CoV-2 weighted prevalence was 1.26% (95% CI 0.43, 3.26) overall and 0.53% (95% CI 0.06, 2.78) and 2.70% (95% CI 0.57, 9.19) in hospital-1 and hospital-2, respectively although the study was underpowered to detect statistically significant differences. The overall, hospital-1, and hospital-2 seroprevalence was 10, 4 and 22 times higher than the estimated infection attack rate in general population, respectively. Suboptimal use of personal protective equipment was noted in both hospitals. These data have implications for the preparedness of a second wave of COVID-19 epidemic, given the low burden of SARS-CoV-2 infection rate, in concordance with national projections.
登录
查看更多内容
DOI：
10.1016/s1473-3099(20)30634-4
发表时间：
2020-12
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
National SARS-CoV-2 Serology Assay Evaluation Group
通讯作者：
National SARS-CoV-2 Serology Assay Evaluation Group
影响因子：
2.2
作者：
Kim, Jaeho;Kim, Moon-Moo
通讯作者：
Kim, Moon-Moo
影响因子：
13.8
作者：
Kluytmans-van Den Bergh, Marjolein F. Q.;Buiting, Anton G. M.;Kluytmans, Jan A. J. W.
通讯作者：
Kluytmans, Jan A. J. W.
影响因子：
8.8
作者：
Korth, Johannes;Wilde, Benjamin;Herrmann, Anke
通讯作者：
Herrmann, Anke
影响因子：
4.4
作者：
Brandstetter, Susanne;Roth, Samra;Kabesch, Michael
通讯作者：
Kabesch, Michael