SARS-CoV-2 antibody prevalence in health care workers: Preliminary report of a single center study.
SARS-CoV-2 antibody prevalence in health care workers: Preliminary report of a single center study.
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DOI：
10.1371/journal.pone.0240006
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Hara J
中科院分区：
文献类型：
--
作者：
Brant-Zawadzki M;Fridman D;Robinson PA;Zahn M;Chau C;German R;Breit M;Bock JR;Hara J
已进行血清学调查，以确定COVID-19抗体在不同人群和社区的患病率，并报告了广泛的结果。这些抗体在医护人员中的流行率，被认为具有较高的感染风险，已经得到越来越多的研究，需要更多的研究来更好地了解不同医疗环境中的风险和感染传播。本研究报告了2020年5月和6月期间在加州橙子县区域医院系统对医护人员进行的初始血清监测。研究对象是从整个医院员工队伍和独立的医务人员中招募的。收集的数据包括工作职责和地点、COVID-19症状、PCR检测史、自2020年1月以来的旅行记录以及是否存在与COVID-19的家庭接触。从每名受试者中采集血液样本，用于SARS-CoV-2 IgG抗体的血清分析。在2，992名受试者中，共有2，924名具有完整数据的人被纳入分析。观察到的患病率为1.06%（31例抗体阳性病例），确定了检测灵敏度和特异性的校正患病率为1.13%。在年龄（z = 2.65，p = 0.008）、种族（p = 0.037）、发热（p <0.001）和嗅觉丧失（p <0.001）方面观察到阳性与阴性之间存在显著的组间差异，但在职业方面没有差异（p = 0.710）。这种低患病率的可能解释包括检测时当地地理社区患病率相对较低（~4.4%）、医院及时采购个人防护设备、严格的员工教育、患者分诊以及治疗方案的制定和实施。此外，交叉反应性适应性T细胞介导的免疫，如最近所述，可能发挥更大的作用，在医护人员比一般人群。
Serological surveys have been conducted to establish prevalence for COVID-19 antibodies in various cohorts and communities, reporting a wide range of outcomes. The prevalence of such antibodies among healthcare workers, presumed at higher risk for infection, has been increasingly investigated, more studies are needed to better understand the risks and infection transmission in different healthcare settings. The present study reports on initial sero-surveillance conducted on healthcare workers at a regional hospital system in Orange County, California, during May and June, 2020. Study subjects were recruited from the entire hospital employee workforce and the independent medical staff. Data were collected for job duties and locations, COVID-19 symptoms, a PCR test history, travel record since January 2020, and existence of household contacts with COVID-19. A blood sample was collected from each subject for serum analysis for IgG antibodies to SARS-CoV-2. Of 2,992 tested individuals, a total 2,924 with complete data were included in the analysis. Observed prevalence of 1.06% (31 antibody positive cases), adjusted prevalence of 1.13% for test sensitivity and specificity were identified. Significant group differences between positive vs. negative were observed for age (z = 2.65, p = .008), race (p = .037), presence of fever (p < .001), and loss of smell (p < .001), but not for occupations (p = .710). Possible explanation for this low prevalence includes a relatively low local geographic community prevalence (~4.4%) at the time of testing, the hospital’s timely procurement of personal protective equipment, rigorous employee education, patient triage, and treatment protocol development and implementation. In addition, cross-reactive adaptive T cell mediated immunity, as recently described, may possibly play a greater role in healthcare workers than in the general population.
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