Maternal stress induces adult reduced REM sleep and melatonin level.
Maternal stress induces adult reduced REM sleep and melatonin level.
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DOI：
10.1002/dneu.20961
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发表时间：
2012-05
影响因子：
3
通讯作者：
Guo, Yang
中科院分区：
文献类型：
--
作者：
Feng, Pingfu;Hu, Yufen;Vurbic, Drina;Guo, Yang
我们以前曾报道过，新生儿母亲剥夺（MD）导致总睡眠减少和食欲素A在成年大鼠中的增加。现在，我们的特点的睡眠，活动，和褪黑激素水平的大鼠脑内治疗MD和控制（MC）程序。成年雄性Sprague道利大鼠在出生后第4天开始用MD或MC程序处理10天。在三个月大时，在一组MD和MC大鼠中记录48小时的睡眠，而另一组MD和MC大鼠测量自发活动（在LD=12：12下）。测量血液、松果体和下丘脑中的褪黑激素水平以及下丘脑中的时钟蛋白水平。与MC大鼠相比，MD大鼠的REM睡眠在光照期显著减少，但在黑暗期没有减少。与MC大鼠相比，MD大鼠的安静觉醒和总觉醒在光照期显著增加。MD大鼠松果体重量明显小于MC大鼠。与MC组相比，MD组的松果体和下丘脑中的褪黑素水平显著降低。在下丘脑中的时钟蛋白的表达中，没有发现组间的显著差异。新生儿MD导致REM睡眠和褪黑激素水平降低，而运动活动的昼夜节律周期和时钟蛋白水平没有变化。
We have previously reported that neonatal maternal deprivation (MD) resulted in a decrease of total sleep and an increase of orexin A in adult rats. Now, we characterized features of sleep, activity, and melatonin levels in rats neonatally treated with MD and control (MC) procedures. Adult male Sprague Dawley rats were treated with either MD or MC procedures for ten days starting at postnatal day 4. At three months of age, sleep was recorded for 48 hours in one set of MD and MC rats while another set of MD and MC rats were measured for locomotor activity (under LD=12:12). Melatonin levels in the blood, pineal gland, and hypothalamus were measured as well as clock protein level in the hypothalamus. Compared with the MC rats, REM sleep in the MD rats was significantly reduced in the light periods but not in the dark periods. Both quiet wake and total wake in the MD rats were significantly increased during the light period compared to the MC rats. The weight of the pineal gland of the MD rats was significantly smaller than in MC rats. Melatonin levels of the MD group were significantly reduced in the pineal gland and hypothalamus compared with the MC group. No significant difference was identified between groups in the expression of the clock protein in the hypothalamus. Neonatal MD resulted in reduced REM sleep and melatonin levels, without changes of circadian cycle of locomotor activity and levels of clock protein.
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影响因子：
2.9
作者：
Bendz, Lisa M.;Scates, Ann C.
通讯作者：
Scates, Ann C.
影响因子：
5.6
作者：
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作者：
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作者：
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作者：
FOLKARD, S;ARENDT, J;CLARK, M
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