Aberrant Expression of a Proliferation-Inducing Ligand Underlies Autoimmune Mechanisms in Immune Thrombocytopenia.
Aberrant Expression of a Proliferation-Inducing Ligand Underlies Autoimmune Mechanisms in Immune Thrombocytopenia.
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增殖诱导配体的异常表达是免疫性血小板减少症自身免疫机制的基础
DOI：
10.1155/2021/3676942
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发表时间：
2021
影响因子：
4.1
通讯作者：
Tai WL
中科院分区：
文献类型：
--
作者：
Hao YF;Bi H;Li HY;Yin LM;Yu JX;Tao W;Mu HL;Yang RC;Zhou ZP;Tai WL
To study the relationship between surface membrane-bound APRIL and ITP. The peripheral blood of all subjects, 50 patients diagnosed with ITP and 25 healthy controls, was collected. Flow cytometry was used to detect the expression of membrane-bound APRIL on immune cells and platelets. ELISA was used to detect the content of soluble APRIL in plasma. Membrane-bound APRIL was only expressed on the surface of platelets in both ITP patients and controls. APRIL expression on the platelet surface was significantly lower in newly diagnosed (P < 0.001) and chronic (P < 0.001) ITP patients than in controls. Platelet surface APRIL level was significantly enhanced in patients with complete remission after treatment (P = 0.02) but not in those with no response after treatment. Platelet surface APRIL level in ITP patients was negatively correlated with serum APRIL level (r = −0.09765, P = 0.0424). Platelet surface APRIL may play a key immunoregulative role. Platelet surface APRIL is likely to be one source of the excessive serum APRIL in ITP patients. The effectiveness of treatment may be measured by determining the platelet surface APRIL levels in ITP patients.
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DOI：
10.3760/cma.j.issn.0253-2727.2016.02.001
发表时间：
2016-02
影响因子：
--
作者：
Thrombosis and Hemostasis Group, Hematology Society, Chinese Medical Association
通讯作者：
Thrombosis and Hemostasis Group, Hematology Society, Chinese Medical Association
影响因子：
9.1
作者：
Jonsson, MV;Szodoray, P;Skarstein, K
通讯作者：
Skarstein, K
DOI：
10.1002/cptx.46
发表时间：
2018-05
期刊：
Current protocols in toxicology
影响因子：
--
作者：
Loelius SG;Spinelli SL;Lannan KL;Phipps RP
通讯作者：
Phipps RP
影响因子：
11.4
作者：
Pradet-Balade, B;Medema, JP;Hahne, M
通讯作者：
Hahne, M
影响因子：
30.5
作者：
Litinskiy, MB;Nardelli, B;Cerutti, A
通讯作者：
Cerutti, A