Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk.
Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk.
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DOI：
10.1038/s41398-021-01713-z
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发表时间：
2021-11-13
影响因子：
6.8
通讯作者：
Polimanti R
中科院分区：
文献类型：
--
作者：
De Angelis F;Wendt FR;Pathak GA;Tylee DS;Goswami A;Gelernter J;Polimanti R
饮酒和吸烟是与广泛的不良健康结果相关的危险行为。在这项研究中，我们探讨了与每周饮酒，开始吸烟年龄，开始吸烟，每天吸烟和戒烟相关的多基因风险评分（PRS）与费城神经发育队列的4498名欧洲血统的儿童和年轻人（8-21岁）的433种精神和行为特征的关系。在应用错误发现率多重检验校正后，我们确定了36个与精神病症状、情感和年龄识别社交能力、言语推理、焦虑相关特征、父母教育和物质使用相关的协会。这些关联独立于饮酒和吸烟特征与认知表现、教育程度、冒险行为和精神病理学之间的遗传相关性。删除赞同物质使用的参与者并不影响每个PRS与发现分析中确定为显着的精神和行为特征的关联。基因本体富集分析确定了几个神经生物学过程的PRS协会的机制，我们的报告。总之，我们对儿童和年轻人吸烟和饮酒行为的遗传重叠提供了新的见解，突出了他们与精神病理学和物质使用的独立性。
Alcohol drinking and tobacco smoking are hazardous behaviors associated with a wide range of adverse health outcomes. In this study, we explored the association of polygenic risk scores (PRS) related to drinks per week, age of smoking initiation, smoking initiation, cigarettes per day, and smoking cessation with 433 psychiatric and behavioral traits in 4498 children and young adults (aged 8–21) of European ancestry from the Philadelphia neurodevelopmental cohort. After applying a false discovery rate multiple testing correction accounting for the number of PRS and traits tested, we identified 36 associations related to psychotic symptoms, emotion and age recognition social competencies, verbal reasoning, anxiety-related traits, parents’ education, and substance use. These associations were independent of the genetic correlations among the alcohol-drinking and tobacco-smoking traits and those with cognitive performance, educational attainment, risk-taking behaviors, and psychopathology. The removal of participants endorsing substance use did not affect the associations of each PRS with psychiatric and behavioral traits identified as significant in the discovery analyses. Gene-ontology enrichment analyses identified several neurobiological processes underlying mechanisms of the PRS associations we report. In conclusion, we provide novel insights into the genetic overlap of smoking and drinking behaviors in children and young adults, highlighting their independence from psychopathology and substance use.
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