Association of Peripheral Interleukin-6 with Global Cognitive Decline in Non-demented Adults: A Meta-Analysis of Prospective Studies.
Association of Peripheral Interleukin-6 with Global Cognitive Decline in Non-demented Adults: A Meta-Analysis of Prospective Studies.
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DOI：
10.3389/fnagi.2017.00438
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发表时间：
2017
影响因子：
4.8
通讯作者：
Murgatroyd CA
中科院分区：
文献类型：
--
作者：
Bradburn S;Sarginson J;Murgatroyd CA
背景资料：在认知能力下降的个体中报告了全身性炎症的生物标志物升高，然而，大多数文献关注的是产生混合结果的横断面分析。本研究通过对前瞻性研究进行荟萃分析来研究这种关联的病因，这些前瞻性研究调查了基线白细胞介素-6（IL-6）（外周炎症的既定标志物）与随访时非痴呆成年人认知能力下降风险之间的关系。研究方法：我们通过检索PubMed、Science Direct、Scopus和Google Scholar数据库，回顾了截至2017年2月报告外周IL-6与未来认知功能下降的研究。在随机效应模型中汇总了包含循环基线IL-6与非痴呆社区居住老年人纵向认知表现之间关联的比值比（OR）的研究。结果如下：文献检索检索到5，642篇潜在文献，其中7篇包含8个独立老化队列的文献符合审查条件。总体而言，这些研究包括15，828名基线参与者。在随访2-7年期间，与低IL-6的患者相比，高循环IL-6的患者在随访时发生整体认知功能下降的可能性高1.42倍（OR 1.42，95% CI 1.18-1.70; p < 0.001）。亚组和敏感性分析表明，这种关联与研究样本量、随访持续时间和使用的认知评估无关。结论：这些结果进一步证明了通过血液IL-6测量的高外周炎症与整体认知能力下降之间的相关性。测量循环中的IL-6可能是未来认知健康的有用指标。
Background: Elevated biomarkers of systemic inflammation have been reported in individuals with cognitive decline, however, most of the literature concerns cross-sectional analyses that have produced mixed results. This study investigates the etiology of this association by performing meta-analyses on prospective studies investigating the relationship between baseline interleukin-6 (IL-6), an established marker of peripheral inflammation, with cognitive decline risk in non-demented adults at follow-up. Methods: We reviewed studies reporting peripheral IL-6 with future cognitive decline, up to February 2017 by searching the PubMed, Science Direct, Scopus and Google Scholar databases. Studies which contained odds ratios (ORs) for the association between circulating baseline IL-6 and longitudinal cognitive performance in non-demented community dwelling older adults were pooled in random-effects models. Results: The literature search retrieved 5,642 potential articles, of which 7 articles containing 8 independent aging cohorts were eligible for review. Collectively, these studies included 15,828 participants at baseline. Those with high circulating IL-6 were 1.42 times more likely to experience global cognitive decline at follow-up, over a 2–7-year period, compared to those with low IL-6 (OR 1.42, 95% CI 1.18–1.70; p < 0.001). Subgroup and sensitivity analyses suggests that this association is independent of the study sample size, duration of follow-up and cognitive assessments used. Conclusions: These results add further evidence for the association between high peripheral inflammation, as measured by blood IL-6, and global cognitive decline. Measuring circulating IL-6 may be a useful indication for future cognitive health.
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DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
3.7
作者：
Compté N;Boudjeltia KZ;Vanhaeverbeek M;De Breucker S;Pepersack T;Tassignon J;Trelcat A;Goriely S
通讯作者：
Goriely S
影响因子：
9.2
作者：
Erta M;Quintana A;Hidalgo J
通讯作者：
Hidalgo J
影响因子：
1.3
作者：
Li, Danni;Yu, Fang
通讯作者：
Yu, Fang
影响因子：
2.7
作者：
Donzis, Elissa J.;Tronson, Natalie C.
通讯作者：
Tronson, Natalie C.