Expression of CD40 and CD40L in gastric cancer tissue and its clinical significance.
Expression of CD40 and CD40L in gastric cancer tissue and its clinical significance.
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CD40和CD40L在胃癌组织中的表达及其临床意义
DOI：
10.3390/ijms10093900
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发表时间：
2009-09-04
影响因子：
5.6
通讯作者：
Zhang XG
中科院分区：
文献类型：
--
作者：
Li R;Chen WC;Pang XQ;Hua C;Li L;Zhang XG
为了研究CD40和CD40L在胃癌组织中的表达，我们评估了苏州大学附属第一医院消化科收治的胃癌患者和对照组。从患者获得胃癌和正常（来自肿瘤周围）组织样品。胃癌组和溃疡组于手术前1天清晨抽取静脉血，测定外周血sCD 40 L水平。应用免疫组化方法检测胃癌组织中CD 40的表达。根据CD40表达的不同，分析患者的年龄、性别、肿瘤大小、大体形态、细胞分化程度、组织学分型、肿瘤浸润深度、淋巴结转移、腹膜播散、TNM分期等临床病理因素。结果表明，胃癌组织中CD40高表达。胃癌组织中CD40的阳性表达与淋巴结转移和TNM分期有关（P < 0.05）。结论：CD40在扩张型胃癌中有较高的表达，对胃癌的临床诊断有重要意义。
To study expression of CD40 and CD40L in gastric cancer tissue we assessed gastric cancer patients admitted to the Department of Gastroenterology of The First Affiliated Hospital of Soochow University and control subjects. Gastric cancer and normal (from around tumours) tissue samples were obtained from patients. Venous blood samples (gastric cancer and ulcer groups) were drawn on the morning of the day before surgery for the measurement of peripheral sCD40L. The expression of CD40 in gastric carcinoma specimens was examined immuno-histochemically. The clinicopathological factors, including age, sex, tumor size, gross appearance, degree of cellular differentiation, histological classification, depth of tumor invasion, lymph node metastasis, peritoneal dissemination, and TNM stage were analyzed according to the different expression of CD40. The results indicated a high CD40 expression in gastric cancer tissues. This positive expression of CD40 revealed a significant (P < 0.05) correlation with lymphatic metastasis and tumor TNM stage in gastric cancer patients. It is concluded that higher CD40 expression existed in expanding type tumors and could play an important role in clinical diagnosis of gastric cancer patients.
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