Plasma membrane localization of the GFL receptor components: a nexus for receptor crosstalk.
Plasma membrane localization of the GFL receptor components: a nexus for receptor crosstalk.
复制标题
DOI：
10.1007/s00441-020-03235-4
复制
发表时间：
2020-10
影响因子：
3.6
通讯作者：
Pierchala BA
中科院分区：
文献类型：
--
作者：
Donnelly CR;Pierchala BA
胶质细胞系来源的神经营养因子（GDNF）家族配体（GFLs）由四组同源的有效生长因子组成，包括GDNF、神经蛋白（NRTN）、阿耳特芬（ARTN）和persephin （PSPN）。gfl的存活、生长和有丝分裂活性由单一受体酪氨酸激酶Ret传递。gfl不直接与Ret结合以激活Ret，而是以高亲和力结合甘油磷脂酰肌醇（GPI）锚定的辅助受体GDNF家族受体-αs （GFRαs）。最近已经确定了几种影响Ret和GFRαs进出质膜的机制，从而影响它们与配体结合的可用性，以及通过靶向降解途径影响它们的水平。本文综述了这些机制及其对GFL信号传导和功能的强大影响。我们还描述了最近的发现，p75和Ret形成一个信号复合体，也由质膜穿梭调节，根据细胞背景增强GFL存活信号或p75促凋亡信号。
The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) comprise a group of four homologous and potent growth factors that includes GDNF, neurturin (NRTN), artemin (ARTN), and persephin (PSPN). The survival, growth, and mitotic activities of the GFLs are conveyed by a single receptor tyrosine kinase, Ret. The GFLs do not bind directly to Ret in order to activate it, and instead bind with high affinity to glycerophosphatidylinositol (GPI)-anchored coreceptors called the GDNF family receptor-αs (GFRαs). Several mechanisms have recently been identified that influence the trafficking of Ret and GFRαs in and out of the plasma membrane, thereby affecting their availability for ligand binding, as well as their levels by targeting to degradative pathways. This review describes these mechanisms and their powerful effects on GFL signaling and function. We also describe the recent discovery that p75 and Ret form a signaling complex, also regulated by plasma membrane shuttling, that either enhances GFL survival signals or p75 pro-apoptotic signals, dependent on the cellular context.
登录
查看更多内容
影响因子：
4.8
作者：
de Chaves, EIP;Vance, DE;Vance, JE
通讯作者：
Vance, JE
影响因子：
7.7
作者：
Fleming MS;Vysochan A;Paixão S;Niu J;Klein R;Savitt JM;Luo W
通讯作者：
Luo W
影响因子：
16.2
作者：
Haase, G;Dessaud, E;deLapeyrière, O
通讯作者：
deLapeyrière, O
影响因子：
56.9
作者：
Deppmann, Christopher D.;Mihalas, Stefan;Ginty, David D.
通讯作者：
Ginty, David D.
影响因子：
8.8
作者：
Chen Z;Donnelly CR;Dominguez B;Harada Y;Lin W;Halim AS;Bengoechea TG;Pierchala BA;Lee KF
通讯作者：
Lee KF