Severely ill and high-risk COVID-19 patients exhibit increased peripheral circulation of CD62L+ and perforin+ T cells.
Severely ill and high-risk COVID-19 patients exhibit increased peripheral circulation of CD62L+ and perforin+ T cells.
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DOI：
10.3389/fimmu.2023.1113932
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发表时间：
2023
影响因子：
7.3
通讯作者：
Beckham, J. David
中科院分区：
文献类型：
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作者：
Lesteberg, Kelsey E.;Araya, Paula;Waugh, Katherine A.;Chauhan, Lakshmi;Espinosa, Joaquin M.;Beckham, J. David
引起 COVID-19 的 SARS-CoV-2 的出现已导致全球报告病例超过 4 亿例。 COVID-19 疾病范围从无症状感染到严重疾病，可能受到个体免疫差异的影响。我们使用多参数流式细胞术来比较重症（ICU 入住）和非重症（入住观察病房）住院 COVID-19 患者的 CD4+ 和 CD8+ T 细胞反应。我们发现，与非重症患者相比，重症 COVID-19 患者表达 CD62L 的 CD4+ T 细胞的频率更高，与康复患者相比，穿孔素+ CD8+ T 细胞的频率更高。此外，与非重症和非糖尿病患者相比，重症糖尿病患者的 CD62L+ CD4+ 和 CD8+ T 细胞频率更高，并且重症高血压患者的 CD62L+ CD4+ T 细胞也有所增加。这是第一份表明 CD62L+ T 细胞和穿孔素 + T 细胞与严重的 COVID-19 疾病相关的报告，并且在患有高风险既往疾病（包括老年和糖尿病）的患者中显着增加。这些数据为严重的 COVID-19 提供了潜在的生物标志物。
The emergence of SARS-CoV-2, which causes COVID-19, has led to over 400 million reported cases worldwide. COVID-19 disease ranges from asymptomatic infection to severe disease and may be impacted by individual immune differences. We used multiparameter flow cytometry to compare CD4+ and CD8+ T cell responses in severe (ICU admitted) and non-severe (admitted to observational unit) hospitalized COVID-19 patients. We found that patients with severe COVID- 19 had greater frequencies of CD4+ T cells expressing CD62L compared to non-severe patients and greater frequencies of perforin+ CD8+ T cells compared to recovered patients. Furthermore, greater frequencies of CD62L+ CD4+ and CD8+ T cells were seen in severely ill diabetic patients compared to non-severe and non-diabetic patients, and increased CD62L+ CD4+ T cells were also seen in severely ill patients with hypertension. This is the first report to show that CD62L+ T cells and perforin+ T cells are associated with severe COVID-19 illness and are significantly increased in patients with high-risk pre-existing conditions including older age and diabetes. These data provide a potential biological marker for severe COVID-19.
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影响因子：
2.3
作者：
Gray TJ;Webb CE
通讯作者：
Webb CE
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
46.9
作者：
Chua, Robert Lorenz;Lukassen, Soeren;Eils, Roland
通讯作者：
Eils, Roland
影响因子：
5.8
作者：
Kared, Hassen;Martelli, Serena;Larbi, Anis
通讯作者：
Larbi, Anis
在动脉粥样硬化之前和开发过程中淋巴细胞募集到主动脉壁是部分依赖性L-选择蛋白。
DOI：
10.1084/jem.20052205
发表时间：
2006-05-15
期刊：
The Journal of experimental medicine
影响因子：
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作者：
通讯作者：
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