Characterisation of Prostate Lesions Using Transrectal Shear Wave Elastography (SWE) Ultrasound Imaging: A Systematic Review.
Characterisation of Prostate Lesions Using Transrectal Shear Wave Elastography (SWE) Ultrasound Imaging: A Systematic Review.
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DOI：
10.3390/cancers13010122
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发表时间：
2021-01-02
期刊：
影响因子：
5.2
通讯作者：
Nabi G
中科院分区：
文献类型：
--
作者：
Anbarasan T;Wei C;Bamber JC;Barr RG;Nabi G
剪切波弹性成像是一种基于超声的成像方式，可以描绘出可能由于癌变而更硬的前列腺病变。利用16项已发表研究的证据，包括2200多例疑似或活检证实的前列腺癌患者，我们表明剪切波弹性成像对前列腺癌的检测具有良好的灵敏度和特异性。背景：基于超声的剪切波弹性成像（SWE）可以无创地评估前列腺组织硬度。本系统性综述旨在评价SWE用于检测前列腺癌（PCa），并比较报告检测所有PCa和临床显著PCa（csPCa）的研究之间的诊断估计值。方法：使用MEDLINE、EMBASE、科克伦图书馆、ClinicalTrials.gov和CINAHL数据库进行文献检索。纳入了使用组织病理学作为参考标准评价SWE检测PCa的研究。结果：纳入16项研究，包括2277例患者进行审查。9项研究使用系统性活检作为每个样本水平的参考标准，评价了SWE检测PCa的效果，合并的灵敏度和特异性分别为0.85（95% CI = 0.74-0.92）和0.85（95% CI = 0.75-0.91）。5项研究使用根治性前列腺切除术（RP）标本的组织病理学作为参考标准，评价了SWE检测PCa的方法，合并灵敏度和特异性分别为0.71（95% CI = 0.55-0.83）和0.74（95% CI = 0.42-0.92）。亚组分析显示，在使用RP标本作为参比标准品的研究中，与所有PCa相比，检测csPCa的合并灵敏度（0.77 vs. 0.62）和特异性（0.84 vs. 0.53）更高。结论：SWE是一种有吸引力的影像学检查PCa。
Shear wave elastography is an ultrasound-based imaging modality that can delineate prostate lesions that are stiffer, possibly due to cancerous changes. Using evidence from 16 published studies, including more than 2200 patients with suspected or biopsy-proven prostate cancer, we showed that shear wave elastography has good sensitivity and specificity for the detection of prostate cancer. Background: ultrasound-based shear wave elastography (SWE) can non-invasively assess prostate tissue stiffness. This systematic review aims to evaluate SWE for the detection of prostate cancer (PCa) and compare diagnostic estimates between studies reporting the detection of all PCa and clinically significant PCa (csPCa). Methods: a literature search was performed using the MEDLINE, EMBASE, Cochrane Library, ClinicalTrials.gov, and CINAHL databases. Studies evaluating SWE for the detection of PCa using histopathology as reference standard were included. Results: 16 studies including 2277 patients were included for review. Nine studies evaluated SWE for the detection of PCa using systematic biopsy as a reference standard at the per-sample level, with a pooled sensitivity and specificity of 0.85 (95% CI = 0.74–0.92) and 0.85 (95% CI = 0.75–0.91), respectively. Five studies evaluated SWE for the detection of PCa using histopathology of radical prostatectomy (RP) specimens as the reference standard, with a pooled sensitivity and specificity of 0.71 (95% CI = 0.55–0.83) and 0.74 (95% CI = 0.42–0.92), respectively. Sub-group analysis revealed a higher pooled sensitivity (0.77 vs. 0.62) and specificity (0.84 vs. 0.53) for detection of csPCa compared to all PCa among studies using RP specimens as the reference standard. Conclusion: SWE is an attractive imaging modality for the detection of PCa.
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