Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy.
Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy.
复制标题
DOI：
10.1016/j.ccr.2014.05.018
复制
发表时间：
2015-01-01
影响因子：
20.6
通讯作者：
Turro C
中科院分区：
文献类型：
--
作者：
Knoll JD;Turro C
利用可见光通过光动力疗法（PDT）产生高选择性和有效的药物在癌症治疗中具有很大的潜力。PDT试剂可以被设计为通过产生高反应性物质（例如1 O2）遵循O2依赖性机制和/或通过诸如激发态电子转移、与DNA的共价结合或光诱导药物递送的过程遵循O2非依赖性机制。Ru（II）-多吡啶和Rh 2（II，II）络合物代表一类重要的化合物，其可以通过明智地选择配体组来定制以表现出所需的物理性质和光化学反应性。具有相对长寿命的激发态和平面的嵌入配体的复合物定位于DNA链上，并通过1 O2产生或由发色团的激发态氧化鸟嘌呤来光裂解DNA。光诱导配体取代通过三重金属中心（3 MC）激发态的群体发生，并促进金属络合物以类似于顺铂的模式共价结合到DNA。配体光解离还提供了一种选择性药物递送的途径。通过配体变化来构建具有所需光吸收和激发态性质的金属络合物的能力使得能够设计能够潜在地从单一金属络合物提供组合疗法的PDT试剂。
The use of visible light to produce highly selective and potent drugs through photodynamic therapy (PDT) holds much potential in the treatment of cancer. PDT agents can be designed to follow an O2-dependent mechanism by producing highly reactive species such as 1O2 and/or an O2 independent mechanism through processes such as excited state electron transfer, covalent binding to DNA or photoinduced drug delivery. Ru(II)-polypyridyl and Rh2(II,II) complexes represent an important class of compounds that can be tailored to exhibit desired photophysical properties and photochemical reactivity by judicious selection of the ligand set. Complexes with relatively long-lived excited states and planar, intercalating ligands localize on the DNA strand and photocleave DNA through 1O2 production or guanine oxidation by the excited state of the chromophore. Photoinduced ligand substitution occurs through the population of triplet metal centered (3MC) excited states and facilitates covalent binding of the metal complex to DNA in a mode similar to cisplatin. Ligand photodissociation also provides a route to selective drug delivery. The ability to construct metal complexes with desired light absorbing and excited state properties by ligand variation enables the design of PDT agents that can potentially provide combination therapy from a single metal complex.
登录
查看更多内容
影响因子：
4.6
作者：
Chouai, A;Wicke, SE;Thummel, RP
通讯作者：
Thummel, RP
影响因子：
4.6
作者：
De Candia, Ariel G.;Marcolongo, Juan P.;Slep, Leonardo D.
通讯作者：
Slep, Leonardo D.
影响因子：
4.9
作者：
Betanzos-Lara, Soledad;Salassa, Luca;Sadler, Peter J.
通讯作者：
Sadler, Peter J.
影响因子：
4.6
作者：
DAS, K;KADISH, KM;BEAR, JL
通讯作者：
BEAR, JL
DOI：
10.1002/hed.10372
发表时间：
2004-03-01
影响因子：
2.9
作者：
D'Cruz, AK;Robinson, MH;Biel, MA
通讯作者：
Biel, MA