The Sec-dependent pathway.

The Sec-dependent pathway.
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DOI:
10.1016/j.resmic.2013.03.007
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发表时间:
2013-07
影响因子:
2.6
通讯作者:
Beckwith, Jon
Beckwith, Jon
中科院分区:
生物学3区
文献类型:
--
作者:
Beckwith, Jon

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蛋白质通过细胞质膜输出到细菌周质和外膜的Sec途径是在细菌中发现的第一个分泌途径。细菌遗传学的组合,在体外膜囊泡系统的发展和同时阐述的信号假说从真核生物的研究导致的识别和表征的两个途径,导致蛋白质出口通过SecYEG细胞质膜易位。Sec途径也是蛋白质组装到细胞质膜中所必需的。由于Sec途径的膜转位子在生命的三个领域中是保守的,真核生物和细菌的研究进展历史是由研究这两类生物的人之间的密切相互作用促进的。
The Sec pathway for export of proteins across the cytoplasmic membrane to the bacterial periplasm and outer membrane was the first secretion pathway to be discovered in bacteria. A combination of bacterial genetics, development of an in vitro membrane vesicle system and the concurrent elaboration of the signal hypothesis from studies on eukaryotes led to the identification and characterization of two pathways leading to protein export through the SecYEG cytoplasmic membrane translocon. The Sec pathway is also required for assembly of proteins into the cytoplasmic membrane. Since the membrane translocon for Sec pathways is conserved across the three domains of life, the history of research progress in eukaryotes and bacteria was facilitated by the close interaction between those studying both classes of organisms.
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