Associations between type I interferon and antiphospholipid antibody status differ between ancestral backgrounds.
Associations between type I interferon and antiphospholipid antibody status differ between ancestral backgrounds.
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I型干扰素和抗磷脂抗体状态之间的关联在祖先背景之间有所不同。
DOI：
10.1136/lupus-2017-000246
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发表时间：
2018
影响因子：
3.9
通讯作者：
Niewold TB
中科院分区：
文献类型：
--
作者：
Iwamoto T;Dorschner J;Jolly M;Huang X;Niewold TB
系统性红斑狼疮患者体内I型干扰素途径被激活，抗双链α和抗核糖核酸结合蛋白自身抗体与干扰素α的高活性相关。我们研究了不应刺激Toll样受体的抗磷脂抗体是否也与高水平的干扰素α活性有关。采用Wish细胞生物法检测系统性红斑狼疮患者血清干扰素α活性。在临床实验室检测IgGAPL、抗RBP和抗dsDNA抗体，并以标准的临床分界值确定阳性结果。高干扰素α活性与抗RBP和抗双链DNA抗体相关。值得注意的是，APL抗体检测阳性的非裔美国人的干扰素α活性高于那些没有IgGAPL抗体的人。这与其他祖先的背景没有相同之处。这一发现独立于其他自身抗体谱，而且在IgGAPL抗体阳性和阴性的非裔美国人患者中，临床特征没有差异。不同祖先背景的干扰素α活性和免疫球蛋白APL状态之间的关联差异支持分子发病机制的差异。这可能表明非洲裔美国人中存在I型干扰素背景下的B细胞过度活动，并可能提出个性化治疗的方法。
The type I interferon pathway is activated in many patients with systemic lupus erythematosus (SLE), and anti-double-stranded DNA (dsDNA) and anti-RNA binding protein autoantibodies are correlated with high interferon-α (IFNα) activity. We studied whether antiphospholipid (APL) antibodies, which should not stimulate Toll-like receptors, are also associated with high levels of IFNα activity. Serum IFNα activity was measured in patients with SLE using the WISH cell bioassay. IgG APL, anti-RBP and anti-dsDNA antibodies were measured in the clinical laboratory, and standard clinical cut-offs were used to define the positive results. High IFNα activity was associated with anti-RBP and anti-dsDNA antibodies in all three ancestral backgrounds. Strikingly, African-American subjects with a positive APL antibody test had higher IFNα activity than those without IgG APL antibodies. This was not shared with other ancestral backgrounds. This finding was independent of other autoantibody profiles, and clinical features did not differ between IgG APL antibody positive versus negative African-American patients. The difference in association between IFNα activity and IgG APL status between ancestral backgrounds supports differences in molecular pathogenesis. This may suggest B cell hyperactivity in the setting of type I IFN in African-Americans and could suggest ways to individualise therapy.
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影响因子：
13.6
作者：
Borchers, Andrea T.;Naguwa, Stanley M.;Gershwin, M. Eric
通讯作者：
Gershwin, M. Eric
影响因子：
8
作者：
Menard, Laurence C.;Habte, Sium;Suchard, Suzanne J.
通讯作者：
Suchard, Suzanne J.
干扰素α类差异诱导中和抗Interferonα抗体，可降低干扰素诱导的和B细胞激活相关的转录本的表达：分析来自干扰素α激体I/II期研究的扩展后续数据。
DOI：
10.1093/rheumatology/kew262
发表时间：
2016-10
期刊：
Rheumatology (Oxford, England)
影响因子：
--
作者：
Ducreux J;Houssiau FA;Vandepapelière P;Jorgensen C;Lazaro E;Spertini F;Colaone F;Roucairol C;Laborie M;Croughs T;Grouard-Vogel G;Lauwerys BR
通讯作者：
Lauwerys BR
DOI：
10.1016/j.trsl.2014.10.005
发表时间：
2015-02
期刊：
Translational research : the journal of laboratory and clinical medicine
影响因子：
--
作者：
Crow MK;Olferiev M;Kirou KA
通讯作者：
Kirou KA
影响因子：
--
作者：
Kirou, KA;Lee, C;Crow, MK
通讯作者：
Crow, MK