A migrant study of pubertal timing and tempo in British-Bangladeshi girls at varying risk for breast cancer.
A migrant study of pubertal timing and tempo in British-Bangladeshi girls at varying risk for breast cancer.
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DOI：
10.1186/s13058-014-0469-8
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发表时间：
2014-11-15
期刊：
影响因子：
--
通讯作者：
Katki HA
中科院分区：
文献类型：
--
作者：
Houghton LC;Cooper GD;Bentley GR;Booth M;Chowdhury OA;Troisi R;Ziegler RG;Hoover RN;Katki HA
初潮早与随后的乳腺癌风险有关，但在其他青春期里程碑的年龄和节奏及其与体重指数（BMI）的关系方面的国际差异尚未在不同乳腺癌风险的人群中建立。我们比较了年龄和节奏的肾上腺初长，乳房初长，阴毛初长，月经初潮在移民研究的孟加拉国女孩到英国（英国），并评估是否移民的差异解释了BMI的差异。包括孟加拉国（n = 168），英国-孟加拉国（n = 174）和白色英国（n = 54）的女孩，年龄在5至16岁。访问者管理的问卷获得青春期分期，身高和体重进行了测量。唾液硫酸脱氢表雄酮浓度> 400 pg/ml定义为肾上腺初显。根据Weibull生存模型估计青春期里程碑的中位年龄和风险比（HR）及95%置信区间（CI）。在所有三组中，肾上腺初显发生最早，其次是乳房初显，阴毛初显，最后是月经初潮。肾上腺初潮时的中位年龄（孟加拉人= 7.2，英国-孟加拉人= 7.4，白色英国人= 7.1; P趋势= 0.70）和初潮时的中位年龄（孟加拉人= 12.5，英国-孟加拉人= 12.1，白色英国人= 12.6; P趋势= 0.70）在各组之间均无差异。相比之下，在英国生活的女孩中，乳房初长的中位年龄（孟加拉人= 10.7，英国-孟加拉人= 9.6，英国白色人= 8.7; P趋势<0.01）发生得更早。与孟加拉国女孩相比，乳房发育早的HR（95%CI）为1.6（1.1至2.4）英国-孟加拉国女孩和2.6（1.5至4.4）为白色英国女孩（P趋势<0.01），但在调整BMI后减弱（英国-孟加拉国人= 1.1（0.7至1.8），英国白色人= 1.7（1.0至3.1）; P趋势= 0.20）。乳房发育发生较早，但青春期进展较慢，随着暴露于英国环境;差异部分解释了更大的BMI。生长环境可能是各国之间和各国内部青春期发育存在种族差异的主要原因。本文的在线版本（doi：10.1186/s13058 - 014 - 0469 - 8）包含补充材料，可供授权用户使用。
Earlier menarche is related to subsequent breast cancer risk, yet international differences in the age and tempo of other pubertal milestones and their relationships with body mass index (BMI) are not firmly established in populations at differing risk for breast cancer. We compared age and tempo of adrenarche, thelarche, pubarche, and menarche in a migrant study of Bangladeshi girls to the United Kingdom (UK) and assessed whether differences by migration were explained by differences in BMI. Included were groups of Bangladeshi (n =168), British-Bangladeshi (n =174) and white British (n =54) girls, aged 5 to 16 years. Interviewer-administered questionnaires obtained pubertal staging; height and weight were measured. Salivary dehydroepiandrosterone-sulfate concentrations >400 pg/ml defined adrenarche. Median ages of pubertal milestones and hazard ratios (HR) with 95% confidence intervals (CI) were estimated from Weibull survival models. In all three groups, adrenarche occurred earliest, followed by thelarche, pubarche, and finally menarche. Neither median age at adrenarche (Bangladeshi = 7.2, British-Bangladeshi = 7.4, white British = 7.1; P-trend = 0.70) nor at menarche (Bangladeshi = 12.5, British-Bangladeshi = 12.1, white British = 12.6; P-trend = 0.70) differed across groups. In contrast, median age at thelarche (Bangladeshi = 10.7, British-Bangladeshi = 9.6, white British = 8.7; P-trend <0.01) occurred earlier among girls living in the UK. Compared with Bangladeshi girls, HRs (95% CI) for earlier thelarche were 1.6 (1.1 to 2.4) for British-Bangladeshi girls and 2.6 (1.5 to 4.4) for white British girls (P-trend <0.01), but were attenuated after adjustment for BMI (British-Bangladeshi = 1.1 (0.7 to 1.8), white British = 1.7(1.0 to 3.1); P-trend =0.20). Thelarche occurred earlier, but puberty progressed slower with increasing exposure to the UK environment; differences were partially explained by greater BMI. The growth environment might account for much of the ethnic differences in pubertal development observed across and within countries. The online version of this article (doi:10.1186/s13058-014-0469-8) contains supplementary material, which is available to authorized users.
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影响因子：
8
作者：
Biro FM;Galvez MP;Greenspan LC;Succop PA;Vangeepuram N;Pinney SM;Teitelbaum S;Windham GC;Kushi LH;Wolff MS
通讯作者：
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