Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls.
Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls.
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DOI：
10.1542/peds.2009-3079
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发表时间：
2010-09
期刊：
影响因子：
8
通讯作者：
Wolff MS
中科院分区：
文献类型：
--
作者：
Biro FM;Galvez MP;Greenspan LC;Succop PA;Vangeepuram N;Pinney SM;Teitelbaum S;Windham GC;Kushi LH;Wolff MS
本研究的目的是描述评估方法和成熟状态的多地点队列的女孩在基线招募和年龄7和8岁。青春期成熟分期的方法是在3个研究中心合作开发的。在3个地点招募了6至8岁的女孩：东哈莱姆，纽约;大辛辛那提都市区;和旧金山弗朗西斯科湾区，加州。基线特征通过与护理人员的访谈和由受过训练的检查人员进行的人体测量获得;乳房2期被定义为青春期成熟的开始。κ统计量用于评估主培训师和考官之间的一致性。Logistic回归模型用于确定与青春期成熟相关的因素，线性回归模型用于检查与身高增长速度相关的因素。基线队列包括1239名女孩。达到乳房2期的女孩比例因年龄、人种/种族、BMI百分位数和研究中心而异。7年时，10.4%的白色、23.4%的非西班牙裔黑人和14.9%的西班牙裔女孩达到乳房分期≥2; 8年时，分别有18.3%、42.9%和30.9%达到乳房分期≥2。身高增长速度的主要决定因素是青春期状态。在这项多中心研究中，各中心检查员之间关于青春期分期的意见基本一致。在7岁和8岁时乳房发育的女孩比例，特别是白色女孩的比例，高于对10至30岁前出生的女孩的研究报告。
The objective of this study was to describe the assessment methods and maturation status for a multisite cohort of girls at baseline recruitment and at ages 7 and 8 years. The method for pubertal maturation staging was developed collaboratively across 3 sites. Girls at ages 6 to 8 years were recruited at 3 sites: East Harlem, New York; greater Cincinnati metropolitan area; and San Francisco Bay area, California. Baseline characteristics were obtained through interviews with caregivers and anthropometric measurements by trained examiners; breast stage 2 was defined as onset of pubertal maturation. The κ statistic was used to evaluate agreement between master trainers and examiners. Logistic regression models were used to identify factors that are associated with pubertal maturation and linear regression models to examine factors that are associated with height velocity. The baseline cohort included 1239 girls. The proportion of girls who had attained breast stage 2 varied by age, race/ethnicity, BMI percentile, and site. At 7 years, 10.4% of white, 23.4% of black non-Hispanic, and 14.9% of Hispanic girls had attained breast stage ≥2; at 8 years, 18.3%, 42.9%, and 30.9%, respectively, had attained breast stage ≥2. The prime determinant of height velocity was pubertal status. In this multisite study, there was substantial agreement regarding pubertal staging between examiners across sites. The proportion of girls who had breast development at ages 7 and 8 years, particularly among white girls, is greater than that reported from studies of girls who were born 10 to 30 years earlier.
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通讯作者：
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