Enhanced inotropic response to dobutamine in strength-trained subjects with left ventricular hypertrophy.
Enhanced inotropic response to dobutamine in strength-trained subjects with left ventricular hypertrophy.
复制标题
左心室肥大的力量训练受试者对多巴酚丁胺的正性肌力反应增强。
DOI：
10.1152/jappl.2000.88.2.534
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Ehsani,AA
中科院分区：
文献类型：
--
作者：
Suman,OE;Hasten,D;Turner,MJ;Rinder,MR;Spina,RJ;Ehsani,AA
为了确定力量训练的生理性向心性左心室（LV）肥大个体是否表现出对儿茶酚胺增强的正性肌力反应，我们研究了11名年龄为33.0 ± 2（SE）岁的健美运动员和10名年龄为31.3 ± 2.4岁的久坐不动的健康受试者，在基线和阿托品后递增剂量多巴酚丁胺输注期间。健美运动员有较大的左心室质量，后壁和间隔壁厚度，壁厚半径比，评估与二维超声心动图，比久坐不动的主题。无论训练状态如何，左心室质量和瘦体重之间存在显著相关性。两组的基线LV缩短分数相似。有一个更大的正性肌力反应多巴酚丁胺在力量训练的个人，证明了一个陡峭的斜率的分数缩短收缩末期室壁应力的关系与较高的轴截距和一个较浅的收缩末期室壁应力收缩末期直径的关系没有改变舒张末期直径。力量训练组运动员对多巴酚丁胺的心率反应减弱。健美运动员对多巴酚丁胺的正性肌力敏感性与左室重量之间存在显著相关性（r= 0.604，P < 0.05）。这些数据表明，在阻力训练的个人向心性左室生理性肥大与增强的变力性，但不是变时性反应，儿茶酚胺。
To determine whether strength-trained individuals with physiological concentric left ventricular (LV) hypertrophy exhibit enhanced inotropic responses to catecholamines, we studied 11 bodybuilders, aged 33.0 ± 2 (SE) yr old, and 10 sedentary healthy subjects, aged 31.3 ± 2.4 yr old, at baseline and during infusion of incremental doses of dobutamine after atropine. The bodybuilders had larger LV mass, posterior wall and septal wall thicknesses, and wall thickness-to-radius ratio, assessed with two-dimensional echocardiography, than did the sedentary subjects. There was a significant correlation between LV mass and lean body mass irrespective of training status. Baseline LV fractional shortening was similar in the two groups. There was a greater inotropic response to dobutamine in the strength-trained individuals, as evidenced by a steeper slope of the fractional shortening-end-systolic wall stress relationship with a highery-axis intercept and by a shallower end-systolic wall stress-end systolic diameter relationship without changes in end-diastolic diameter. The heart rate response to dobutamine was attenuated in the strength-trained athletes. There was a significant correlation (r= 0.604,P< 0.05) between the inotropic sensitivity to dobutamine and LV mass normalized for lean body mass in the bodybuilders. The data suggest that concentric LV physiological hypertrophy in the resistance-trained individuals is associated with enhanced inotropic but not chronotropic responses to catecholamines.
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DOI：
10.1152/jappl.1997.83.6.1900
发表时间：
1997
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
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影响因子：
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EHSANI, AA
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
R. Spina;T. Ogawa;A. Coggan;J. Holloszy;A. Ehsani
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