Exosomes as mediators of intercellular crosstalk in metabolism.
Exosomes as mediators of intercellular crosstalk in metabolism.
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DOI：
10.1016/j.cmet.2021.08.006
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发表时间：
2021-09-07
期刊：
影响因子：
29
通讯作者：
Olefsky JM
中科院分区：
文献类型：
--
作者：
Isaac R;Reis FCG;Ying W;Olefsky JM
外泌体是由所有细胞类型分泌的纳米颗粒，并且是称为细胞外囊泡（EV）的更广泛类别的纳米颗粒的大组分。一旦分泌，外泌体进入间隙空间并最终进入循环，在那里它们发挥局部旁分泌或远端全身作用。因此，外泌体是细胞间和器官内通信系统的重要组成部分，能够将生物信号从一种细胞类型或组织携带到另一种细胞类型或组织。外泌体的货物由蛋白质、脂质、miRNA和其他RNA种类组成，并且外泌体的许多生物学效应已归因于miRNA。外泌体miRNA也被用作疾病生物标志物。外泌体生物学和代谢领域正在迅速扩大，定期出现新的发现和报告，并且在不久的将来可能会启动在代谢疾病中使用外泌体或miRNA的潜在治疗方法。
Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes gain access to the interstitial space and ultimately the circulation, where they exert local paracrine or distal systemic effects. Because of this, exosomes are important components of an intercellular and intraorgan communication system capable of carrying biologic signals from one cell type or tissue to another. The exosomal cargo consists of proteins, lipids, miRNAs, and other RNA species, and many of the biologic effects of exosomes have been attributed to miRNAs. Exosomal miRNAs have also been used as disease biomarkers. The field of exosome biology and metabolism is rapidly expanding, with new discoveries and reports appearing on a regular basis, and it is possible that potential therapeutic approaches for the use of exosomes or miRNAs in metabolic diseases will be initiated in the near future.
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影响因子：
29
作者：
Crewe C;Funcke JB;Li S;Joffin N;Gliniak CM;Ghaben AL;An YA;Sadek HA;Gordillo R;Akgul Y;Chen S;Samovski D;Fischer-Posovszky P;Kusminski CM;Klein S;Scherer PE
通讯作者：
Scherer PE
影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
影响因子：
7.3
作者：
Andreu Z;Yáñez-Mó M
通讯作者：
Yáñez-Mó M
影响因子：
4.3
作者：
Bertoldi, Karine;Cechinel, Laura Reck;Siqueira, Ionara Rodrigues
通讯作者：
Siqueira, Ionara Rodrigues
DOI：
10.1073/pnas.1808855115
发表时间：
2018-11-27
影响因子：
11.1
作者：
Castano, Carlos;Kalko, Susana;Parrizas, Marcelina
通讯作者：
Parrizas, Marcelina