Health impacts of estrogens in the environment, considering complex mixture effects.
Health impacts of estrogens in the environment, considering complex mixture effects.
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DOI：
10.1289/ehp.10443
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发表时间：
2007-12
影响因子：
10.4
通讯作者：
Tyler CR
中科院分区：
文献类型：
--
作者：
Filby AL;Neuparth T;Thorpe KL;Owen R;Galloway TS;Tyler CR
环境雌激素在废水处理工作（WWTW）的流出物是公认的野生鱼类种群生殖中断的主要原因，但其可能的作用，更广泛的健康影响的流出物尚未建立。我们评估了雌激素对暴露于WwTW废水的模式鱼类中诱导的不良健康影响的贡献，并比较了雌激素单独和作为复杂混合物的一部分（即，掺入流出物中）。比较了黑头呆鱼（黑头呆鱼）暴露于强雌激素流出物、类固醇雌激素[17α-乙炔基雌二醇（EE 2）]加标前后的弱雌激素流出物和单独EE 2 21天后的生长、遗传毒性、免疫毒性、代谢和内分泌（雌性化）反应。除了内分泌干扰，污水暴露引起的遗传毒性损伤，调节免疫功能，改变代谢，许多这些影响引起的性别特异性的方式和成比例的雌激素效力的污水。一个关键的发现是，当EE 2存在于复杂的混合物中时，对EE 2的一些反应被改变（即，掺入污水中），这表明混合物的影响可能不容易模拟污水排放或当化学品对各种生物轴的影响。这些数据揭示了污水中存在的雌激素与不同的、不利的和与性别有关的健康影响之间的明确联系。我们的研究结果还强调需要更好地了解化学毒物对生物系统的相互作用，以了解环境混合物对健康的影响。
Environmental estrogens in wastewater treatment work (WwTW) effluents are well established as the principal cause of reproductive disruption in wild fish populations, but their possible role in the wider health effects of effluents has not been established. We assessed the contribution of estrogens to adverse health effects induced in a model fish species by exposure to WwTW effluents and compared effects of an estrogen alone and as part of a complex mixture (i.e., spiked into effluent). Growth, genotoxic, immunotoxic, metabolic, and endocrine (feminized) responses were compared in fathead minnows (Pimephales promelas) exposed for 21 days to a potent estrogenic effluent, a weakly estrogenic effluent before and after spiking with a steroidal estrogen [17α-ethinyl-estradiol (EE2)], and to EE2 alone. In addition to endocrine disruption, effluent exposure induced genotoxic damage, modulated immune function, and altered metabolism; many of these effects were elicited in a sex-specific manner and were proportional to the estrogenic potencies of the effluents. A key finding was that some of the responses to EE2 were modified when it was present in a complex mixture (i.e., spiked into effluent), suggesting that mixture effects may not be easily modeled for effluent discharges or when the chemicals impact on a diverse array of biological axes. These data reveal a clear link between estrogens present in effluents and diverse, adverse, and sex-related health impacts. Our findings also highlight the need for an improved understanding of interactive effects of chemical toxicants on biological systems for understanding health effects of environmental mixtures.
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影响因子：
3.8
作者：
Buhler, DR;Miranda, CL;Wang-Buhler, JL
通讯作者：
Wang-Buhler, JL
影响因子：
5.8
作者：
Doi, AM;Pham, RT;Gallagher, EP
通讯作者：
Gallagher, EP
DOI：
10.1124/jpet.301.1.160
发表时间：
2002-04-01
影响因子：
3.5
作者：
Lin, HL;Kent, UM;Hollenberg, PF
通讯作者：
Hollenberg, PF
影响因子：
11.4
作者：
Jobling, S;Nolan, M;Sumpter, JP
通讯作者：
Sumpter, JP
影响因子：
3.6
作者：
Jobling, S;Coey, S;Sumpter, JP
通讯作者：
Sumpter, JP