Sex differences for phenotype in pathologically defined dementia with Lewy bodies.
Sex differences for phenotype in pathologically defined dementia with Lewy bodies.
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DOI：
10.1136/jnnp-2020-325668
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Litvan I
中科院分区：
文献类型：
--
作者：
Bayram E;Coughlin DG;Banks SJ;Litvan I
在临床定义的队列中报告了路易体痴呆（DLB）的性别差异;然而，DLB的临床诊断准确性不理想，并且尚未在病理证实的参与者中评估表型差异。在国家阿尔茨海默病协调中心，对55名女性和156名男性的DLB核心特征进行了比较。对年龄、教育和tau负荷匹配的55名女性和55名男性重复这些分析。在总样本中，女性死亡年龄较大，受教育年限较少，tau蛋白负荷较高，但被诊断为痴呆和临床DLB的可能性较小。在匹配的样本中，幻视在女性中仍然不太常见，符合临床DLB标准的女性较少。性别影响DLB潜在病理的临床表现。尽管有类似的潜在路易体病理，妇女不太可能表现出核心DLB功能，并可能在临床上诊断不足。
Sex differences in dementia with Lewy bodies (DLB) have been reported in clinically defined cohorts; however, clinical diagnostic accuracy in DLB is suboptimal and phenotypic differences have not been assessed in pathologically confirmed participants. Core DLB features were compared across 55 women and 156 men with pathologically defined DLB in the National Alzheimer’s Coordinating Center. These analyses were repeated for 55 women and 55 men matched for age, education and tau burden. In the total sample, women died older, had fewer years of education, had higher tau burden but were less likely to be diagnosed with dementia and clinical DLB. In the matched sample, visual hallucinations continued to be less common in women, and fewer women met clinical DLB criteria. Sex impacts clinical manifestations of underlying pathologies in DLB. Despite similar underlying Lewy body pathology, women are less likely to manifest core DLB features and may be clinically underdiagnosed.
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DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
基线神经精神症状和发生轻度认知障碍的风险：一项基于人群的研究。
DOI：
10.1176/appi.ajp.2014.13060821
发表时间：
2014-05
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Geda YE;Roberts RO;Mielke MM;Knopman DS;Christianson TJ;Pankratz VS;Boeve BF;Sochor O;Tangalos EG;Petersen RC;Rocca WA
通讯作者：
Rocca WA
影响因子：
2.1
作者：
Besser L;Kukull W;Knopman DS;Chui H;Galasko D;Weintraub S;Jicha G;Carlsson C;Burns J;Quinn J;Sweet RA;Rascovsky K;Teylan M;Beekly D;Thomas G;Bollenbeck M;Monsell S;Mock C;Zhou XH;Thomas N;Robichaud E;Dean M;Hubbard J;Jacka M;Schwabe-Fry K;Wu J;Phelps C;Morris JC;Neuropsychology Work Group, Directors, and Clinical Core leaders of the National Institute on Aging-funded US Alzheimer’s Disease Centers
通讯作者：
Neuropsychology Work Group, Directors, and Clinical Core leaders of the National Institute on Aging-funded US Alzheimer’s Disease Centers
影响因子：
2.1
作者：
Corrada, Maria M.;Berlau, Daniel J.;Kawas, Claudia H.
通讯作者：
Kawas, Claudia H.
影响因子：
8.6
作者：
Gamez-Valero, Ana;Prada-Dacasa, Patricia;Beyer, Katrin
通讯作者：
Beyer, Katrin