Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: a population-based study.
Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: a population-based study.
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基线神经精神症状和发生轻度认知障碍的风险：一项基于人群的研究。
DOI：
10.1176/appi.ajp.2014.13060821
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Rocca WA
中科院分区：
文献类型：
--
作者：
Geda YE;Roberts RO;Mielke MM;Knopman DS;Christianson TJ;Pankratz VS;Boeve BF;Sochor O;Tangalos EG;Petersen RC;Rocca WA
在梅奥老年临床研究的背景下，我们进行了一项前瞻性队列研究，通过基线神经精神状态来估计轻度认知损害(MCI)的发生率。一个专家共识小组根据公布的标准对正常认知老化、MCI和痴呆症的分类进行了裁决。以年龄为时间尺度，用COX比例风险模型计算危险比(HR)和95%可信区间(95%CI)。对1587名认知正常的人进行了至少一次随访，获得了神经精神病学问卷调查的基线数据。我们跟踪队列(N=1,587)到事件MCI(N=365)或审查变量(N=179)，中位数为5年。在调整了年龄、性别、教育程度和医学共病后，下列基线神经精神症状显著预测MCI的发生：激动(HR=3.06；95%CI=1.89-4.93)、冷漠(HR=2.26；95%CI=1.49-3.41)、焦虑(HR=1.87；95%CI=1.28-2.73)、易怒(HR=1.84；95%CI=1.31-2.58)和抑郁(HR=1.63；95%CI=1.23-2.16)。妄想(HR=0.55；95%CI=0.08~3.95)和幻觉(HR=1.48；95%CI=0.37~5.99)不能预测MCI的发生。二次分析显示，兴奋(HR=11.3；95%CI=3.44~37.2)、去抑制(HR=5.18；95%CI=2.24~12.0)和夜间行为(HR=2.04；95%CI=1.11~3.76)是非遗忘性MCI的显著预测因素，而对遗忘性MCI无显著预测作用。相反，抑郁预示遗忘型MCI(HR=1.74；95%CI=1.22-2.47)，而不预示非遗忘型MCI(HR=1.18；95%CI=0.64-2.16)。非精神病性症状可预测MCI事件。然而，基线欣快感、去抑制、妄想、幻觉和事件MCI的结果之间的关联应该被认为是初步的，因为观察是基于少量事件。
We conducted a prospective cohort study to estimate the incidence of mild cognitive impairment (MCI) by baseline neuropsychiatric status, in the setting of the Mayo Clinic Study of Aging. A classification of normal cognitive aging, MCI, and dementia was adjudicated by an expert consensus panel based on published criteria. Hazard ratios (HR) and 95% confidence intervals (95% CI) were computed using Cox proportional hazards model, with age as a time scale. Baseline Neuropsychiatric Inventory Questionnaire data were available on 1,587 cognitively normal persons who underwent at least one follow-up visit. We followed the cohort (N=1,587) to incident MCI (N=365) or censoring variables (N=179) for a median of 5 years. The following baseline neuropsychiatric symptoms significantly predicted incident MCI, after adjusting for age, sex, education and medical comorbidity: agitation (HR=3.06; 95% CI=1.89–4.93), apathy (HR=2.26; 95% CI=1.49–3.41), anxiety (HR=1.87; 95% CI=1.28–2.73), irritability (HR=1.84; 95% CI=1.31–2.58), and depression (HR=1.63; 95% CI=1.23–2.16). Delusion (HR=0.55; 95% CI=0.08–3.95) and hallucination (HR=1.48; 95% CI=0.37–5.99) did not predict incident MCI. A secondary analysis showed that euphoria (HR=11.3; 95% CI=3.44–37.2), disinhibition (HR=5.18; 95% CI=2.24–12.0) and nighttime behavior (HR=2.04; 95% CI=1.11–3.76) were significant predictors of non-amnestic MCI but not of amnestic MCI. By contrast, depression predicted amnestic MCI (HR=1.74; 95% CI=1.22–2.47) but not non-amnestic MCI (HR=1.18; 95% CI=0.64–2.16). Non-psychotic symptoms predicted incident MCI. However, the associations between baseline euphoria, disinhibition, delusions, hallucinations, and the outcome of incident MCI should be considered preliminary since the observations were based on small number of events.
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影响因子：
7.2
作者：
DEYO, RA;CHERKIN, DC;CIOL, MA
通讯作者：
CIOL, MA
影响因子：
6.6
作者：
KESSLER, RC;MCGONAGLE, KA;BLAZER, DG
通讯作者：
BLAZER, DG
影响因子：
6.7
作者：
Luck, T.;Riedel-Heller, S. G.;Kaduszkiewicz, H.
通讯作者：
Kaduszkiewicz, H.
影响因子：
7.6
作者：
COSTA, PT;MCCRAE, RR
通讯作者：
MCCRAE, RR
DOI：
10.1076/jcen.20.2.194.1173
发表时间：
1998-04-01
影响因子：
2.2
作者：
Lucas, JA;Ivnik, RJ;Petersen, RC
通讯作者：
Petersen, RC