Evaluation of alternative respiratory syndromes for specific syndromic surveillance of influenza and respiratory syncytial virus: a time series analysis.
Evaluation of alternative respiratory syndromes for specific syndromic surveillance of influenza and respiratory syncytial virus: a time series analysis.
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DOI：
10.1186/1471-2334-9-190
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发表时间：
2009-11-29
影响因子：
3.7
通讯作者：
Churches T
中科院分区：
文献类型：
--
作者：
Schindeler SK;Muscatello DJ;Ferson MJ;Rogers KD;Grant P;Churches T
越来越多的人对综合征监测进行评估，因为它有可能对人群中疾病活动增加进行早期预警。然而，由于难以归因于致病病原体，解释受到阻碍。我们描述了流感和呼吸道合胞病毒（RSV）检测的实验室计数与急诊室（ED）呼吸道诊断的替代分组之间的时间关系。获得了2001年6月1日至2006年12月1日期间新南威尔士州悉尼东南部地区的ED和实验室数据。急诊科就诊次数、实验室确认的RSV阳性病例和流感病例数按周汇总。在控制时间混杂因素的情况下，使用半参数广义加性模型（GAM）来确定RSV和流感的发病率与呼吸综合征ED发生率之间的关系。在同一周内，RSV实验室计数每增加一次，毛细支气管炎的ED诊断增加3.1% （95%CI: 2.7%-3.5%）。每增加一次流感实验室计数，一周前诊断为流感样疾病的ED增加4.7% （95%CI: 4.2%-5.2%）。在本研究中，毛细支气管炎和流感样疾病的ED诊断的大量增加分别是RSV和流感活性的独立和代理指标。
Syndromic surveillance is increasingly being evaluated for its potential for early warning of increased disease activity in the population. However, interpretation is hampered by the difficulty of attributing a causative pathogen. We described the temporal relationship between laboratory counts of influenza and respiratory syncytial virus (RSV) detection and alternative groupings of Emergency Department (ED) respiratory diagnoses. ED and laboratory data were obtained for the south-eastern area of Sydney, NSW for the period 1 June 2001 - 1 December 2006. Counts of ED visits and laboratory confirmed positive RSV and influenza cases were aggregated by week. Semi-parametric generalized additive models (GAM) were used to determine the association between the incidence of RSV and influenza and the incidence of respiratory syndrome ED presentations while controlling for temporal confounders. For every additional RSV laboratory count, ED diagnoses of bronchiolitis increased by 3.1% (95%CI: 2.7%-3.5%) in the same week. For every additional influenza laboratory count, ED diagnoses of influenza-like illness increased by 4.7% (95%CI: 4.2%-5.2%) one week earlier. In this study, large increases in ED diagnoses of bronchiolitis and influenza-like illness were independent and proxy indicators for RSV and influenza activity, respectively.
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影响因子：
4.2
作者：
M端ller-Pebody, B;Edmunds, WJ;Crowcroft, NS
通讯作者：
Crowcroft, NS
影响因子：
11.8
作者：
Buehler JW;Berkelman RL;Hartley DM;Peters CJ
通讯作者：
Peters CJ
影响因子：
6.2
作者：
Bourgeois, FT;Olson, KL;Mandl, KD
通讯作者：
Mandl, KD
影响因子：
28.2
作者：
Cooper, D. L.;Smith, G. E.;George, R. C.
通讯作者：
George, R. C.
影响因子：
4.5
作者：
Muscatello DJ;Churches T;Kaldor J;Zheng W;Chiu C;Correll P;Jorm L
通讯作者：
Jorm L